Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/94160
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dc.contributor.authorTu, Wei-Linzh_TW
dc.contributor.authorCheng, Chuen-Yuzh_TW
dc.contributor.authorWang, Shih-Hanzh_TW
dc.contributor.authorTang, Pin-Chizh_TW
dc.contributor.authorChen, Chih-Fengzh_TW
dc.contributor.authorChen, Hsin-Hsinzh_TW
dc.contributor.authorLee, Yen-Paizh_TW
dc.contributor.authorChen, Shuen-Eizh_TW
dc.contributor.authorHuang, San-Yuanzh_TW
dc.contributor.author黃三元zh_TW
dc.date2016-02-
dc.date.accessioned2017-08-01T04:10:35Z-
dc.date.available2017-08-01T04:10:35Z-
dc.identifier.urihttp://hdl.handle.net/11455/94160-
dc.description.abstractAcute heat stress severely impacts poultry production. The hypothalamus acts as a crucial center to regulate body temperature, detect temperature changes, and modulate the autonomic nervous system and endocrine loop for heat retention and dissipation. The purpose of this study was to investigate global gene expression in the hypothalamus of broiler-type B strain Taiwan country chickens after acute heat stress. Twelve 30-week-old hens were allocated to four groups. Three heat-stressed groups were subjected to acute heat stress at 38 °C for 2 hours without recovery (H2R0), with 2 hours of recovery (H2R2), and with 6 hours of recovery (H2R6). The control hens were maintained at 25 °C. At the end, hypothalamus samples were collected for gene expression analysis. The results showed that 24, 11, and 25 genes were upregulated and 41, 15, and 42 genes were downregulated in H2R0, H2R2, and H2R6 treatments, respectively. The expressions of gonadotropin-releasing hormone 1 (GNRH1), heat shock 27-kDa protein 1 (HSPB1), neuropeptide Y (NPY), and heat shock protein 25 (HSP25) were upregulated at all recovery times after heat exposure. Conversely, the expression of TPH2 was downregulated at all recovery times. A gene ontology analysis showed that most of the differentially expressed genes were involved in biological processes including cellular processes, metabolic processes, localization, multicellular organismal processes, developmental processes, and biological regulation. A functional annotation analysis showed that the differentially expressed genes were related to the gene networks of responses to stress and reproductive functions. These differentially expressed genes might be essential and unique key factors in the heat stress response of the hypothalamus in chickens.zh_TW
dc.language.isoenzh_TW
dc.relationTheriogenology, Volume 85, Issue 3, Page(s) 483-494.e8.zh_TW
dc.subjectAcute heat stresszh_TW
dc.subjectGene expressionzh_TW
dc.subjectHypothalamuszh_TW
dc.subjectMicroarray analysiszh_TW
dc.subjectTaiwan country chickenzh_TW
dc.subjectAnimalszh_TW
dc.subjectChickenszh_TW
dc.subjectDown-Regulationzh_TW
dc.subjectFemalezh_TW
dc.subjectGene Expression Profilingzh_TW
dc.subjectGonadotropin-Releasing Hormonezh_TW
dc.subjectHSP27 Heat-Shock Proteinszh_TW
dc.subjectHeat-Shock Responsezh_TW
dc.subjectHot Temperaturezh_TW
dc.subjectHypothalamuszh_TW
dc.subjectNeuropeptide Yzh_TW
dc.subjectRNA, Messengerzh_TW
dc.subjectTaiwanzh_TW
dc.subjectTryptophan Hydroxylasezh_TW
dc.subjectUp-Regulationzh_TW
dc.titleProfiling of differential gene expression in the hypothalamus of broiler-type Taiwan country chickens in response to acute heat stresszh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.theriogenology.2015.09.028zh_TW
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.fulltextwith fulltext-
item.grantfulltextrestricted-
item.openairetypeJournal Article-
Appears in Collections:動物科學系
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