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標題: Inhibitory effects of Phyllanthus emblica L. on hepatic steatosis and liver fibrosis in vitro
作者: Chi-Cheng Lu
Shu-Han Yang
Shih-Min Hsia
Chi-Hao Wu
Gow-Chin Yen
關鍵字: Phyllanthus emblica;NAFLD;Free fatty acid;Leptin;Hepatic fibrosis
Project: Journal of Functional Foods, Volume 20, January 2016, Pages 20-30
Phyllanthus emblica L. exerts multiple biological functions, and its fruit possesses
hepatoprotective benefits. However, the underlying mechanisms of these activities remain
unclear. This study aimed to investigate the potential impact of P. emblica on improving nonalcoholic
fatty liver disease (NAFLD). Free fatty acid mixture-induced HepG2 cells and leptininduced
HSC-T6 hepatic stellate cells were used to mimic nonalcoholic steatohepatitis and
hepatic fibrosis, respectively. Ellagic acid (EA) was identified as a major compound in the
water extract of P. emblica fruits (WEPL). WEPL significantly decreased fat accumulation and
ROS production by altering lipogenesis-related gene expression and stimulating AMPactivated
protein kinase (AMPK) signalling in treated HepG2 cells.WEPL also inhibited hepatic
fibrosis in HSC-T6 cells and induced mitochondrial apoptosis. Importantly, EA was shown
to inhibit cellular steatosis and liver fibrosis in vitro. In conclusion, WEPL reduces lipogenesis
in hepatocytes and fibrotic cells, suggesting that WEPL has the potential to improve
DOI: 10.1016/j.jff.2015.10.012
Appears in Collections:食品暨應用生物科技學系

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