Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/94717
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dc.contributor.authorChen, Ya-Hueyzh_TW
dc.contributor.authorChung, Chiao-Chenzh_TW
dc.contributor.authorLiu, Yu-Chiazh_TW
dc.contributor.authorYeh, Su-Pengzh_TW
dc.contributor.authorHsu, Jennifer Lzh_TW
dc.contributor.authorHung, Mien-Chiezh_TW
dc.contributor.authorSu, Hong-Linzh_TW
dc.contributor.authorLi, Long-Yuanzh_TW
dc.contributor.author李龍緣zh_TW
dc.date2016-
dc.date.accessioned2018-02-08T05:26:47Z-
dc.date.available2018-02-08T05:26:47Z-
dc.identifier.urihttp://hdl.handle.net/11455/94717-
dc.description.abstractMesenchymal stem cells (MSCs) are multipotent precursors that can undergo multilineage differentiation, including osteogenesis and adipogenesis, which are two mutually exclusive events. Previously, we demonstrated that enhancer of zeste homolog 2 (EZH2), the catalytic component of the Polycomb-repressive complex 2, mediates epigenetic silencing of histone deacetylase 9c (HDAC9c) in adipocytes but not in osteoblasts and that HDAC9c accelerates osteogenesis while attenuating adipogenesis of MSCs through inactivation of peroxisome proliferator-activated receptor gamma 2 activity. Importantly, disrupting the balance between adipogenesis and osteogenesis can lead to age-associated bone loss (osteoporosis) and obesity. Here, we investigated the relationship between age, and osteogenic and adipogenic differentiation potential of MSCs by comparing EZH2 and HDAC9c expression in osteoblasts and adipocytes of both human and mice origins to determine whether the EZH2-HDAC9c axis regulates age-associated osteoporosis and obesity. Our findings indicated that a decline in HDAC9c expression over time was accompanied by increased EZH2 expression and suggested that a therapeutic intervention for age-associated osteoporosis and obesity may be feasible by targeting the EZH2-HDAC9c axis. Stem Cells 2016;34:2183-2193.zh_TW
dc.language.isoenzh_TW
dc.relationStem cells (Dayton, Ohio), Volume 34, Issue 8, Page(s) 2183-93.zh_TW
dc.subjectAdipogenesiszh_TW
dc.subjectAgingzh_TW
dc.subjectEZH2zh_TW
dc.subjectHDAC9czh_TW
dc.subjectMesenchymal stem cellszh_TW
dc.subjectOsteogenesiszh_TW
dc.subjectAdipocyteszh_TW
dc.subjectAdipogenesiszh_TW
dc.subjectAdolescentzh_TW
dc.subjectAdultzh_TW
dc.subjectAgedzh_TW
dc.subjectAged, 80 and overzh_TW
dc.subjectAgingzh_TW
dc.subjectAnimalszh_TW
dc.subjectChildzh_TW
dc.subjectEnhancer of Zeste Homolog 2 Proteinzh_TW
dc.subjectGene Knockdown Techniqueszh_TW
dc.subjectHistone Deacetylaseszh_TW
dc.subjectHumanszh_TW
dc.subjectMesenchymal Stromal Cellszh_TW
dc.subjectMicezh_TW
dc.subjectMiddle Agedzh_TW
dc.subjectModels, Biologicalzh_TW
dc.subjectOsteoblastszh_TW
dc.subjectOsteogenesiszh_TW
dc.subjectRepressor Proteinszh_TW
dc.subjectYoung Adultzh_TW
dc.subjectCell Differentiationzh_TW
dc.titleEnhancer of Zeste Homolog 2 and Histone Deacetylase 9c Regulate Age-Dependent Mesenchymal Stem Cell Differentiation into Osteoblasts and Adipocyteszh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1002/stem.2400zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextwith fulltext-
item.languageiso639-1en-
item.grantfulltextrestricted-
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