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標題: Azithromycin impairs TLR7 signaling in dendritic cells and improves the severity of imiquimod-induced psoriasis-like skin inflammation in mice
作者: Huang, Shi-Wei
Chen, Yi-Ju
Wang, Sin-Ting
Ho, Li-Wei
Kao, Jun-Kai
Narita, Miwako
Takahashi, Masuhiro
Wu, Chun-Ying
Cheng, Hsuan-Yu
Shieh, Jeng-Jer
關鍵字: Azithromycin;Imiquimod;Psoriasis;Toll-like receptor 7;Aminoquinolines;Animals;Anti-Bacterial Agents;Azithromycin;Cell Proliferation;Cytokines;Dendritic Cells;Disease Models, Animal;Female;Humans;Keratinocytes;Leukocytes, Mononuclear;Lysosomes;Membrane Glycoproteins;Mice;Mice, Inbred BALB C;Psoriasis;Signal Transduction;Skin;Spleen;Th17 Cells;Toll-Like Receptor 7
Project: Journal of dermatological science, Volume 84, Issue 1, Page(s) 59-70.
The activation of Toll-like receptor 7 (TLR7) in dendritic cells (DCs) plays a crucial role in the pathogenesis of psoriasis. The macrolide antibiotic azithromycin (AZM) had been demonstrated to inhibit the TLR4 agonist-induced maturation and activation of murine bone marrow-derived DCs (BMDCs).
DOI: 10.1016/j.jdermsci.2016.07.007
Appears in Collections:生物醫學研究所

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