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標題: | Aryl Hydrocarbon Receptor Deficiency Attenuates Oxidative Stress-Related Mesangial Cell Activation and Macrophage Infiltration and Extracellular Matrix Accumulation in Diabetic Nephropathy | 作者: | Lee, Wen-Jane Liu, Shing-Hwa Chiang, Chih-Kang Lin, Shih-Yi Liang, Kae-Woei Chen, Cheng-Hsu Tien, Hsing-Ru Chen, Pei-Hsuan Wu, Jen-Pey Tsai, Yi-Ching Lai, De-Wei Chang, Yi-Chieh Sheu, Wayne Huey-Herng Sheu, Meei-Ling |
關鍵字: | Animals;Basic Helix-Loop-Helix Transcription Factors;Benzoflavones;Blood Glucose;Diabetes Mellitus, Experimental;Diabetic Nephropathies;Extracellular Matrix;Gene Expression Regulation;Lipid Peroxidation;Macrophages;Mesangial Cells;Mice;Oxidative Stress;Reactive Oxygen Species;Receptors, Aryl Hydrocarbon;Streptozocin | Project: | Antioxidants & redox signaling, Volume 24, Issue 4, Page(s) 217-231. | 摘要: | Activation of glomerular mesangial cells (MCs) and functional changes of renal tubular cells are due to metabolic abnormalities, oxidative stress, and matrix accumulation in the diabetic nephropathy (DN). Aryl hydrocarbon receptor (AhR) activation has been implicated in DN. In this study, we investigated the role of AhR in the pathophysiological processes of DN using AhR knockout (AhRKO) and pharmacological inhibitor α-naphthoflavone mouse models. |
URI: | http://hdl.handle.net/11455/94796 | DOI: | 10.1089/ars.2015.6310 |
Appears in Collections: | 生物醫學研究所 |
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