Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/94816
DC FieldValueLanguage
dc.contributor.authorChen, Ying-Tsongzh_TW
dc.contributor.authorSiu, L Kristopherzh_TW
dc.contributor.authorTsai, Yu-Kuozh_TW
dc.contributor.authorLin, Fu-Meizh_TW
dc.contributor.authorKoh, Tse Hsienzh_TW
dc.contributor.authorChen, Jiun-Hanzh_TW
dc.date2016-03-
dc.date.accessioned2018-04-30T07:13:38Z-
dc.date.available2018-04-30T07:13:38Z-
dc.identifier.urihttp://hdl.handle.net/11455/94816-
dc.description.abstractBacteria encoding the New Delhi metallo-β-lactamase gene (blaNDM-1) are regarded as superbugs for their resistance to multiple antibiotics. Plasmids encoding blaNDM-1 have been observed to be spreading among gram-negative bacteria around the world. Previous studies have demonstrated that multiple modifications of blaNDM-1-harboring plasmids might contribute to the spread of the gene. In this study, we analyzed blaNDM-1-encoding plasmids from two Klebsiella pneumoniae isolates, DU7433 and DU1301, found to be unrelated by pulsed field gel electrophoresis and multilocus sequencing typing (DU7433: ST14 and DU1301: ST11), and compared them with previously published plasmids. Although strains DU1301, DU7433, and previously published strain DU43320 carried unrelated plasmids, their transconjugants exhibited similar antimicrobial resistance profiles. Transconjugants lacked the resistance to aztreonam, ciprofloxacin, gentamicin, tetracycline, and trimethoprim/sulfamethoxazole when compared with the corresponding clinical isolates. Plasmids pTR1 from DU1301 and pTR2 from DU7433 had completely different plasmid backbones except a short conserved region of blaNDM-1 and ble flanked with truncated or nontruncated ISAba125 and trpF. The presence of this common region among known blaNDM-1-carrying plasmids implies that the dissemination of blaNDM-1 may be facilitated by mobilization of this conserved immediate region among different plasmids. Control measures should be strictly enforced whenever increasing incidences of epidemiological unrelated strains were identified.zh_TW
dc.language.isoenzh_TW
dc.relationMicrobial drug resistance (Larchmont, N.Y.), Volume 22, Issue 2, Page(s) 109-14.zh_TW
dc.subjectAnti-Bacterial Agentszh_TW
dc.subjectAztreonamzh_TW
dc.subjectBase Sequencezh_TW
dc.subjectCiprofloxacinzh_TW
dc.subjectConjugation, Geneticzh_TW
dc.subjectConserved Sequencezh_TW
dc.subjectDNA, Bacterialzh_TW
dc.subjectDrug Resistance, Multiple, Bacterialzh_TW
dc.subjectElectrophoresis, Gel, Pulsed-Fieldzh_TW
dc.subjectGene Expressionzh_TW
dc.subjectGentamicinszh_TW
dc.subjectHumanszh_TW
dc.subjectKlebsiella Infectionszh_TW
dc.subjectKlebsiella pneumoniaezh_TW
dc.subjectMicrobial Sensitivity Testszh_TW
dc.subjectMultilocus Sequence Typingzh_TW
dc.subjectPlasmidszh_TW
dc.subjectSingaporezh_TW
dc.subjectTetracyclinezh_TW
dc.subjectTrimethoprim, Sulfamethoxazole Drug Combinationzh_TW
dc.subjectbeta-Lactamaseszh_TW
dc.titleA Common Flanking Region in Promiscuous Plasmids Encoding blaNDM-1 in Klebsiella pneumoniae Isolated in Singaporezh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1089/mdr.2015.0132zh_TW
item.openairetypeJournal Article-
item.fulltextno fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:基因體暨生物資訊學研究所
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