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標題: Highly Efficient Synthesis of an Emerging Lipophilic Antioxidant: 2-Ethylhexyl Ferulate
作者: Huang, Kuo-Chuan
Li, Ying
Kuo, Chia-Hung
Twu, Yawo-Kuo
Shieh, Chwen-Jen
關鍵字: 2-ethylhexyl ferulate;artificial neural network;lipase;reduced pressure evaporation system;response surface methodology;Antioxidants;Coumaric Acids;Esters;Hexanols;Lipase;Lipid Peroxidation;Neural Networks (Computer);Solvents
Project: Molecules (Basel, Switzerland), Volume 21, Issue 4, Page(s) 478.
Ferulic acid in ester form has shown a stronger ability in ameliorating certain pathological conditions and inhibiting lipid oxidation. In present study, a solvent-free and reduced pressure evaporation system was developed for lipase-catalyzed synthesis of 2-ethylhexyl ferulate (2-EF) from ferulic acid and 2-ethylhexanol. A Box-Behnken design with response surface methodology (RSM) and artificial neural network (ANN) was selected to model and optimize the process. Based on the yields of 2-EF, reaction temperature was shown to be the most important process factor on the molar conversion among all variables. The residual values and the coefficient of determination (R²) calculated from the design data indicated that ANN was better than RSM in data fitting. Overall, the present lipase-catalyzed approach for 2-EF synthesis at low reaction temperature in a reduced pressure evaporation system shows high 2-EF production efficiency. Notably, this approach can reduce the enzyme denaturation and ferulic acid oxidation that usually occur during long-term biosynthetic operations at high temperature.
DOI: 10.3390/molecules21040478
Appears in Collections:生物科技發展中心

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