Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/94955
標題: Bioassay using blocking temperature: Interparticle interactions between biofunctionalized magnetic nanoparticles conjugated with biotargets
作者: C. Y. Wang
T. W. Yang
D. Shen
K. L. Chen
J. M. Chen
S. H. Liao
J. J. Chieh
H. C. Yang
L. M. Wang
關鍵字: Bioassay;Nanoparticles;Dextrans;Biomarkers;Interactions;Temperature;Platforms;Magnetic Moments;Saturation;Magnetization;Sensitivity;Magnetic Fields
Project: Applied Physics Letters, vol. 110, no. 13, 133701
摘要: 
This paper reports a bioassay of alpha-fetoprotein (AFP) concentration achieved via the measurement of blocking temperature (TB). Biofunctionalized magnetic nanoparticles (BMNs) consisting of anti-alpha-fetoprotein coated onto dextran-coated magnetic nanoparticles composed of Fe3O4 were prepared and then conjugated with AFP biotargets. It was found that both the saturation magnetization and value of TB increased with the concentration of the associated AFP. Furthermore, the dependence of TB of the samples on magnetic field agreed with the interparticle interaction model. Thus, this study demonstrated a platform to detect biomarkers by characterizing TB with a sensitivity limit of 20 ppb of AFP. The promising results obtained for this bioassay can be attributed to the interparticle interactions and Néel motions of magnetic moments in the BMNs.
URI: http://hdl.handle.net/11455/94955
Appears in Collections:物理學系所

Files in This Item:
File Description SizeFormat Existing users please Login
1.4979142.pdf934.66 kBAdobe PDFThis file is only available in the university internal network    Request a copy
Show full item record
 

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.