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標題: 聚乳酸/蒙脫土奈米複合材料支架製備與物性及生物反應性研究
Poly(lactic acid)/montmorillonite nanocomposite scaffolds: Fabrication, characterization and biological properties
作者: 吳政陽
Wu, Cheng-Yang
關鍵字: PLA;聚乳酸;scaffold;composite;支架;複合材料
出版社: 材料工程學研究所
將上述製備出之PLA奈米複合材料及支架,表面披覆具有與人體骨骼相類似結構之磷酸鈣,再將此樣品浸泡於SBF中,可進一步披覆不同表面型態之磷酸鈣。由浸泡CaCl2+(NH4)2HPO4水溶液之實驗結果發現,數種參數在披覆時間同為一天的情況下,於pH=8,溫度=37.5℃時有最佳的披覆條件;再將上述樣品浸泡SBF於一天後,已可發現表面披覆磷酸鈣晶體,顯示了有先經過CaCl2+(NH4)2HPO4水溶液浸泡所披覆之磷酸鈣形成速率較快,經由XRD及EDX證實,為氫氧基磷灰石(hydroxyapatite, HA)結構。並對其進行牛血清蛋白(BSA)之吸附,以初步鑑定其生物相容性。由ATR-FTIR及FE-SEM的結果顯示,有BSA吸附之訊號存在。

Poly(lactic acid) has received considerable attention as a potential replacement for conventional polymer due to its biodegradability and favorable miscibility with other polymers. It is currently being investigated for biomedical application, pharmaceutical controlled release systems and in biodegradable packaging materials. However, the technological development of PLA in this area is limited by its poor thermal stability and mechanical properties. Thus several studies have been devoted to organic/inorganic nanocomposites with the aim to improve their properties.
In this study, we have used organically modified montmorillonite(MMT) as a dispersed phase to prepare the PLA/MMT nanocomposites. The fabricated PLA/MMT nanocomposites were then formed the PLA/MMT scaffolds using NaCl-leaching technique. Both X-ray diffraction data and TEM micrographs of PLA/MMT nanocomposites indicate most of the swelling silicate layer are exfoliated and randomly dispersed into PLA matrix. The PLA/MMT nanocomposites and scaffolds were found to be a bioactive material, as it formed calcium phosphate in the form of hydroxyapatite deposits in a simulated body fluid (SBF). The physical properties and biocompatibility of fabricated nanocomposites and scaffold can also be measured by DMA, GPC, FE-SEM, DSC and XRD.
From the results of FE-SEM after decomposition for 28 days, the porous structure of PLA/MMT nanocomposites and scaffolds were significantly destroyed and the results were consistent with the data of GPC. Interesting, the crystallization of PLA/MMT nanocomposites and scaffolds increase as increasing decomposition period indicating the better polymer chain arrangement after decomposition.
Appears in Collections:材料科學與工程學系

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