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標題: Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells
作者: Chang, Shu-Hao
Huang, Shi-Wei
Wang, Sin-Ting
Chung, Kai-Cheng
Hsieh, Chia-Wei
Kao, Jun-Kai
Chen, Yi-Ju
Wu, Chun-Ying
Shieh, Jeng-Jer
關鍵字: Autophagy;Double-stranded RNA dependent protein kinase;ER stress;Imiquimod;Adenine;Aminoquinolines;Apoptosis;Autophagy;Cell Line, Tumor;Endoplasmic Reticulum;Endoplasmic Reticulum Stress;Endoribonucleases;Fluorescent Antibody Technique;Heat-Shock Proteins;Humans;Indoles;Microtubule-Associated Proteins;Protein-Serine-Threonine Kinases;RNA Interference;RNA, Small Interfering;Reactive Oxygen Species;Sequestosome-1 Protein;Toll-Like Receptor 7;eIF-2 Kinase
Project: Journal of dermatological science, Volume 87, Issue 2, Page(s) 138-148.
Autophagy is a highly conserved cellular catabolic pathway for degradation and recycling of intracellular components in response to nutrient starvation or environmental stress. Endoplasmic reticulum (ER) homeostasis can be disturbed by physiological and pathological influences, resulting in accumulation of misfolded and unfolded proteins in the ER lumen, a condition referred to as ER stress. Imiquimod (IMQ), a Toll-like receptor (TLR) 7 ligand, possesses anti-tumor and anti-viral activities in vitro and in vivo.
DOI: 10.1016/j.jdermsci.2017.04.011
Appears in Collections:生醫工程研究所

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