Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/95845
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dc.contributor.author陳盈璁zh_TW
dc.contributor.authorChen, Ying-Tsongzh_TW
dc.contributor.authorLai, Yi-Chyizh_TW
dc.contributor.authorTan, Mei-Chenzh_TW
dc.contributor.authorHsieh, Li-Yunzh_TW
dc.contributor.authorWang, Jann-Tayzh_TW
dc.contributor.authorShiau, Yih-Ruzh_TW
dc.contributor.authorWang, Hui-Yingzh_TW
dc.contributor.authorLin, Ann-Chizh_TW
dc.contributor.authorLai, Jui-Fenzh_TW
dc.contributor.authorHuang, I-Wenzh_TW
dc.contributor.authorLauderdale, Tsai-Lingzh_TW
dc.date2017-06-28-
dc.date.accessioned2018-10-26T07:14:14Z-
dc.date.available2018-10-26T07:14:14Z-
dc.identifier.urihttp://hdl.handle.net/11455/95845-
dc.description.abstractThe pks gene cluster encodes enzymes responsible for the synthesis of colibactin, a genotoxin that has been shown to induce DNA damage and contribute to increased virulence. The present study investigated the prevalence of pks in clinical K. pneumoniae isolates from a national surveillance program in Taiwan, and identified microbiological and molecular factors associated with pks-carriage. The pks gene cluster was detected in 67 (16.7%) of 400 isolates from various specimen types. Multivariate analysis revealed that isolates of K1, K2, K20, and K62 capsular types (p < 0.001), and those more susceptible to antimicrobial agents (p = 0.001) were independent factors strongly associated with pks-carriage. Phylogenetic studies on the sequence type (ST) and pulsed-field gel electrophoresis patterns indicated that the pks-positive isolates belong to a clonal group of ST23 in K1, a locally expanding ST65 clone in K2, a ST268-related K20 group, and a highly clonal ST36:K62 group. Carriage of rmpA, iutC, and ybtA, the genes associated with hypervirulence, was significantly higher in the pks-positive isolates than the pks-negative isolates (95.5% vs. 13.2%, p < 0.001). Further studies to determine the presence of hypervirulent pks-bearing bacterial populations in the flora of community residents and their association with different disease entities may be warranted.zh_TW
dc.language.isoen_USzh_TW
dc.relationScientific reports, Volume 7, Page(s) 43120.zh_TW
dc.subjectSCIENTIFIC REPORTSzh_TW
dc.titlePrevalence and characteristics of pks genotoxin gene cluster-positive clinical Klebsiella pneumoniae isolates in Taiwanzh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1038/srep43120zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextwith fulltext-
item.languageiso639-1en_US-
item.grantfulltextrestricted-
Appears in Collections:基因體暨生物資訊學研究所
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