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標題: Trivalent chromium induces autophagy by activating sphingomyelin phosphodiesterase 2 and increasing cellular ceramide levels in renal HK2 cells
作者: Yang, Cheng-Lin
Chiou, Shiow-Her
Tai, Wei-Chun
Joseph, Nithila A
Chow, Kuan-Chih
關鍵字: ATAD3A;autophagy;ceramide;dihydrodiol dehydrogense;reactive oxygen species;sphingomyelin phosphodiesterase 2;Autophagy;Cell Line;Ceramides;Chromium;Enzyme Activation;Epithelial Cells;Humans;Kidney;Reactive Oxygen Species;Sphingomyelin Phosphodiesterase
Project: Molecular carcinogenesis, Volume 56, Issue 11, Page(s) 2424-2433.
In this study, we examined the role of autophagy in the initiation of lipid increases in renal epithelial HK2 cells. We found that trivalent chromium [Cr(III)] induced autophagy by activating sphingomyelin phosphodiesterase 2 (SMPD2). SMPD2 increases levels of ceramide and other lipids. Confocal immunofluorescence microscopy showed that signals of ceramide overlapped with LC3, suggesting that ceramide might play an important role in the formation of autophagosome. In conclusion, our data indicate that Cr(III) induces autophagy via structural aberration of organelle membrane, in particular by the increase of lipid compositions in addition to autophagy-associated proteins.
DOI: 10.1002/mc.22689
Appears in Collections:微生物暨公共衛生學研究所

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