1. NCHU Institution Repository
  2. 農業暨自然資源學院
  3. 食品暨應用生物科技學系
Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/96024
標題: Development of special fatty acid composition formulas for improving vitamin B6 status
改善體內維生素B6狀態之特殊脂肪酸組合配方開發
作者: Shu-Yu Huang
黃舒玉
關鍵字: 維生素B6;脂肪酸組成配方;磷酸比哆醛;vitamin B6;formula;pyridoxal 5-phosphate
引用: References Cited 1999, Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico: Lancet, v. 354, no. 9177, p. 447-455. Agnoli, C. et al., 2016, Plasma Riboflavin and Vitamin B-6, but Not Homocysteine, Folate, or Vitamin B-12, Are Inversely Associated with Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition-Varese Cohort: J.Nutr., v. 146, no. 6, p. 1227-1234. Akiba, S., T. Murata, K. Kitatani, and T. Sato, 2000, Involvement of lipoxygenase pathway in docosapentaenoic acid-induced inhibition of platelet aggregation: Biol.Pharm.Bull., v. 23, no. 11, p. 1293-1297. Araujo, P., T. T. Nguyen, L. Froyland, J. Wang, and J. X. Kang, 2008, Evaluation of a rapid method for the quantitative analysis of fatty acids in various matrices: J.Chromatogr.A, v. 1212, no. 1-2, p. 106-113. Bacarin, C. C., A. B. de Sa-Nakanishi, A. Bracht, M. Matsushita, P. Santos, I, M. A. Mori, R. M. de Oliveira, and H. Milani, 2015b, Fish oil prevents oxidative stress and exerts sustained antiamnesic effect after global cerebral ischemia: CNS.Neurol.Disord.Drug Targets., v. 14, no. 3, p. 400-410. Bang, H. O., J. Dyerberg, and N. Hjoorne, 1976b, The composition of food consumed by Greenland Eskimos: Acta Med.Scand., v. 200, no. 1-2, p. 69-73. Bang, H. O., J. Dyerberg, and H. M. Sinclair, 1980c, The composition of the Eskimo food in north western Greenland: Am.J.Clin.Nutr., v. 33, no. 12, p. 2657-2661. Bas, O., A. Songur, O. Sahin, H. Mollaoglu, O. A. Ozen, M. Yaman, O. Eser, H. Fidan, and M. Yagmurca, 2007, The protective effect of fish n-3 fatty acids on cerebral ischemia in rat hippocampus: Neurochem.Int., v. 50, no. 3, p. 548-554. Benistant, C., F. Achard, S. S. Ben, and M. Lagarde, 1996, Docosapentaenoic acid (22:5,n-3): metabolism and effect on prostacyclin production in endothelial cells: Prostaglandins Leukot.Essent.Fatty Acids, v. 55, no. 4, p. 287-292. Bi, X., F. Li, S. Liu, Y. Jin, X. Zhang, T. Yang, Y. Dai, X. Li, and A. Z. Zhao, 2017, omega-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity: J.Clin.Invest, v. 127, no. 5, p. 1757-1771. Boe, C., and C. T. Vangsness, 2015, Fish Oil and Osteoarthritis: Current Evidence: Am.J.Orthop.(Belle.Mead NJ), v. 44, no. 7, p. 302-305. Brussaard, J. H., M. R. Lowik, H. van den Berg, H. A. Brants, and W. Bemelmans, 1997, Dietary and other determinants of vitamin B6 parameters: Eur.J.Clin.Nutr., v. 51 Suppl 3, p. S39-S45. Careaga, M. M., and H. Sprecher, 1984, Synthesis of two hydroxy fatty acids from 7,10,13,16,19-docosapentaenoic acid by human platelets: J.Biol.Chem., v. 259, no. 23, p. 14413-14417. Carpentier, Y. A., L. Portois, A. Sener, and W. J. Malaisse, 2008, Correlation between liver and plasma fatty acid profile of phospholipids and triglycerides in rats: Int.J.Mol.Med., v. 22, no. 2, p. 255-262. Cattaneo, M., R. Lombardi, A. Lecchi, P. Bucciarelli, and P. M. Mannucci, 2001, Low plasma levels of vitamin B(6) are independently associated with a heightened risk of deep-vein thrombosis: Circulation, v. 104, no. 20, p. 2442-2446. Chang, H. Y., J. T. Tzen, S. J. Lin, Y. T. Wu, and E. P. Chiang, 2011, Long-term prednisolone treatments increase bioactive vitamin B6 synthesis in vivo: J.Pharmacol.Exp.Ther., v. 337, no. 1, p. 102-109. Chasan-Taber, L., J. Selhub, I. H. Rosenberg, M. R. Malinow, P. Terry, P. V. Tishler, W. Willett, C. H. Hennekens, and M. J. Stampfer, 1996, A prospective study of folate and vitamin B6 and risk of myocardial infarction in US physicians: J.Am.Coll.Nutr., v. 15, no. 2, p. 136-143. Chew, E. Y., 2017, Dietary Intake of Omega-3 Fatty Acids From Fish and Risk of Diabetic Retinopathy: JAMA, v. 317, no. 21, p. 2226-2227. Chiang, E. P., D. E. Smith, J. Selhub, G. Dallal, Y. C. Wang, and R. Roubenoff, 2005, Inflammation causes tissue-specific depletion of vitamin B6: Arthritis Res.Ther., v. 7, no. 6, p. R1254-R1262. Cho, H. P., M. Nakamura, and S. D. Clarke, 1999, Cloning, expression, and fatty acid regulation of the human delta-5 desaturase: J.Biol.Chem., v. 274, no. 52, p. 37335-37339. Comte, C., S. Bellenger, J. Bellenger, C. Tessier, J. P. Poisson, and M. Narce, 2004, Effects of streptozotocin and dietary fructose on delta-6 desaturation in spontaneously hypertensive rat liver: Biochimie, v. 86, no. 11, p. 799-806. Dalery, K., S. Lussier-Cacan, J. Selhub, J. Davignon, Y. Latour, and J. Genest, Jr., 1995, Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6, pyridoxal phosphate, and folate: Am.J.Cardiol., v. 75, no. 16, p. 1107-1111. Daviglus, M. L., J. Stamler, A. J. Orencia, A. R. Dyer, K. Liu, P. Greenland, M. K. Walsh, D. Morris, and R. B. Shekelle, 1997, Fish consumption and the 30-year risk of fatal myocardial infarction: N.Engl.J.Med., v. 336, no. 15, p. 1046-1053. De, C. R., 2011, n-3 fatty acids in cardiovascular disease: N.Engl.J.Med., v. 364, no. 25, p. 2439-2450. Degenhardt, T. P., N. L. Alderson, D. D. Arrington, R. J. Beattie, J. M. Basgen, M. W. Steffes, S. R. Thorpe, and J. W. Baynes, 2002, Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat: Kidney Int., v. 61, no. 3, p. 939-950. DeRatt, B. N., M. A. Ralat, O. Kabil, Y. Y. Chi, R. Banerjee, and J. F. Gregory, III, 2014, Vitamin B-6 restriction reduces the production of hydrogen sulfide and its biomarkers by the transsulfuration pathway in cultured human hepatoma cells: J.Nutr., v. 144, no. 10, p. 1501-1508. Dhalla, N. S., S. Takeda, and V. Elimban, 2013b, Mechanisms of the beneficial effects of vitamin B6 and pyridoxal 5-phosphate on cardiac performance in ischemic heart disease: Clin.Chem.Lab Med., v. 51, no. 3, p. 535-543. Egnell, M. et al., 2017, B-Vitamin Intake from Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results from the Prospective NutriNet-Sante Cohort: Nutrients., v. 9, no. 5. Ellis, J. M., and K. S. McCully, 1995, Prevention of myocardial infarction by vitamin B6: Res.Commun.Mol.Pathol.Pharmacol., v. 89, no. 2, p. 208-220. Esmaeili, V., A. H. Shahverdi, M. H. Moghadasian, and A. R. Alizadeh, 2015, Dietary fatty acids affect semen quality: a review: Andrology., v. 3, no. 3, p. 450-461. Fairfield, K. M., and R. H. Fletcher, 2002, Vitamins for chronic disease prevention in adults: scientific review: JAMA, v. 287, no. 23, p. 3116-3126. Feener, E. P., and G. L. King, 1997, Vascular dysfunction in diabetes mellitus: Lancet, v. 350 Suppl 1, p. SI9-13. Fonda, M. L., 1993b, Vitamin B6 metabolism and binding to proteins in the blood of alcoholic and nonalcoholic men: Alcohol Clin.Exp.Res., v. 17, no. 6, p. 1171-1178. Fraser, D. A., J. Thoen, A. C. Rustan, O. Forre, and J. Kjeldsen-Kragh, 1999, Changes in plasma free fatty acid concentrations in rheumatoid arthritis patients during fasting and their effects upon T-lymphocyte proliferation: Rheumatology.(Oxford), v. 38, no. 10, p. 948-952. Frayn, K. N., P. Arner, and H. Yki-Jarvinen, 2006, Fatty acid metabolism in adipose tissue, muscle and liver in health and disease: Essays Biochem., v. 42, p. 89-103. Friso, S., P. F. Jacques, P. W. Wilson, I. H. Rosenberg, and J. Selhub, 2001, Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels: Circulation, v. 103, no. 23, p. 2788-2791. Fu, Z., and A. J. Sinclair, 2000, Increased alpha-linolenic acid intake increases tissue alpha-linolenic acid content and apparent oxidation with little effect on tissue docosahexaenoic acid in the guinea pig: Lipids, v. 35, no. 4, p. 395-400. Furth-Walker, D., D. Leibman, and A. Smolen, 1989, Changes in pyridoxal phosphate and pyridoxamine phosphate in blood, liver and brain in the pregnant mouse: J.Nutr., v. 119, no. 5, p. 750-756. Galluzzi, L., E. Vacchelli, J. Michels, P. Garcia, O. Kepp, L. Senovilla, I. Vitale, and G. Kroemer, 2013, Effects of vitamin B6 metabolism on oncogenesis, tumor progression and therapeutic responses: Oncogene, v. 32, no. 42, p. 4995-5004. Garg, M. L., E. Sebokova, A. B. Thomson, and M. T. Clandinin, 1988, Delta 6-desaturase activity in liver microsomes of rats fed diets enriched with cholesterol and/or omega 3 fatty acids: Biochem.J., v. 249, no. 2, p. 351-356. Goldman, D. W., W. C. Pickett, and E. J. Goetzl, 1983, Human neutrophil chemotactic and degranulating activities of leukotriene B5 (LTB5) derived from eicosapentaenoic acid: Biochem.Biophys.Res.Commun., v. 117, no. 1, p. 282-288. Gonczy, P., S. Grill, E. H. Stelzer, M. Kirkham, and A. A. Hyman, 2001, Spindle positioning during the asymmetric first cell division of Caenorhabditis elegans embryos: Novartis.Found.Symp., v. 237, p. 164-175. Green, R., and B. B. Anderson, 1979, Plasma binding of B6 compounds: Methods Enzymol., v. 62, p. 582-585. Gregory, J. F., III, and J. R. Kirk, 1979, Determination of urinary 4-pyridoxic acid using high performance liquid chromatography: Am.J.Clin.Nutr., v. 32, no. 4, p. 879-883. Hamfelt, A., and L. Soderhjelm, 1984b, Plasma pyridoxal phosphate in diabetics: Am.J.Clin.Nutr., v. 39, no. 5, p. 841-843. Hawkes, J. S., M. J. James, and L. G. Cleland, 1991, Separation and quantification of PGE3 following derivatization with panacyl bromide by high pressure liquid chromatography with fluorometric detection: Prostaglandins, v. 42, no. 4, p. 355-368. Hawkes, J. S., M. J. James, and L. G. Cleland, 1992, Biological activity of prostaglandin E3 with regard to oedema formation in mice: Agents Actions, v. 35, no. 1-2, p. 85-87. Hendrickson, S. C., J. D. St Louis, J. E. Lowe, and S. Abdel-aleem, 1997, Free fatty acid metabolism during myocardial ischemia and reperfusion: Mol.Cell Biochem., v. 166, no. 1-2, p. 85-94. Hjelte, L. E., and A. Nilsson, 2005, Arachidonic acid and ischemic heart disease: J.Nutr., v. 135, no. 9, p. 2271-2273. Hostmark, A. T., and A. Haug, 2014, The inverse association between relative abundances of oleic acid and arachidonic acid is related to alpha -linolenic acid: Lipids Health Dis., v. 13, p. 76. Hron, G., R. Lombardi, S. Eichinger, A. Lecchi, P. A. Kyrle, and M. Cattaneo, 2007, Low vitamin B6 levels and the risk of recurrent venous thromboembolism: Haematologica, v. 92, no. 9, p. 1250-1253. Huang, P. H. et al., 2009, Matrix metalloproteinase-9 is essential for ischemia-induced neovascularization by modulating bone marrow-derived endothelial progenitor cells: Arterioscler.Thromb.Vasc.Biol., v. 29, no. 8, p. 1179-1184. Huang, Y. C., H. H. Chang, S. C. Huang, C. H. Cheng, B. J. Lee, S. Y. Cheng, and K. H. Su, 2005, Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill: Nutrition, v. 21, no. 7-8, p. 779-785. HUBER, A. M., S. N. GERSHOFF, and D. M. HEGSTED, 1964, CARBOHYDRATE AND FAT METABOLISM AND RESPONSE TO INSULIN IN VITAMIN B6-DEFICIENT RATS: J.Nutr., v. 82, p. 371-378. Ink, S. L., and L. M. Henderson, 1984, Effect of binding to hemoglobin and albumin on pyridoxal transport and metabolism: J.Biol.Chem., v. 259, no. 9, p. 5833-5837. Jacobo-Cejudo, M. G., R. Valdes-Ramos, A. L. Guadarrama-Lopez, R. V. Pardo-Morales, B. E. Martinez-Carrillo, and L. S. Harbige, 2017, Effect of n-3 Polyunsaturated Fatty Acid Supplementation on Metabolic and Inflammatory Biomarkers in Type 2 Diabetes Mellitus Patients: Nutrients., v. 9, no. 6. James, M. J., L. G. Cleland, R. A. Gibson, and J. S. Hawkes, 1991, Interaction between fish and vegetable oils in relation to rat leucocyte leukotriene production: J.Nutr., v. 121, no. 5, p. 631-637. James, M. J., R. A. Gibson, and L. G. Cleland, 2000b, Dietary polyunsaturated fatty acids and inflammatory mediator production: Am.J.Clin.Nutr., v. 71, no. 1 Suppl, p. 343S-348S. Jang, Y. M., D. W. Kim, T. C. Kang, M. H. Won, N. I. Baek, B. J. Moon, S. Y. Choi, and O. S. Kwon, 2003, Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution: J.Biol.Chem., v. 278, no. 50, p. 50040-50046. Kamat, S. G., and R. Roy, 2016, Evaluation of the effect of n-3 PUFA-rich dietary fish oils on lipid profile and membrane fluidity in alloxan-induced diabetic mice (Mus musculus): Mol.Cell Biochem., v. 416, no. 1-2, p. 117-129. Kandzari, D. E., J. P. Dery, P. W. Armstrong, D. A. Douglas, M. E. Zettler, G. K. Hidinger, A. D. Friesen, and R. A. Harrington, 2005, MC-1 (pyridoxal 5'-phosphate): novel therapeutic applications to reduce ischaemic injury: Expert.Opin.Investig.Drugs, v. 14, no. 11, p. 1435-1442. Kashanian, M., R. Mazinani, and S. Jalalmanesh, 2007, Pyridoxine (vitamin B6) therapy for premenstrual syndrome: Int.J.Gynaecol.Obstet., v. 96, no. 1, p. 43-44. Kaur, G., D. Cameron-Smith, M. Garg, and A. J. Sinclair, 2011, Docosapentaenoic acid (22:5n-3): a review of its biological effects: Prog.Lipid Res., v. 50, no. 1, p. 28-34. Kelly, P. J., V. E. Shih, J. P. Kistler, M. Barron, H. Lee, R. Mandell, and K. L. Furie, 2003, Low vitamin B6 but not homocyst(e)ine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain fortification: Stroke, v. 34, no. 6, p. e51-e54. Kwak, H. K., C. M. Hansen, J. E. Leklem, K. Hardin, and T. D. Shultz, 2002, Improved vitamin B-6 status is positively related to lymphocyte proliferation in young women consuming a controlled diet: J.Nutr., v. 132, no. 11, p. 3308-3313. Lands, W. E., B. Libelt, A. Morris, N. C. Kramer, T. E. Prewitt, P. Bowen, D. Schmeisser, M. H. Davidson, and J. H. Burns, 1992, Maintenance of lower proportions of (n - 6) eicosanoid precursors in phospholipids of human plasma in response to added dietary (n - 3) fatty acids: Biochim.Biophys.Acta, v. 1180, no. 2, p. 147-162. Le, M. L. et al., 2009, Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort study: Cancer Epidemiol.Biomarkers Prev., v. 18, no. 8, p. 2195-2201. Leaf, A., 2001, Plasma nonesterified fatty acid concentration as a risk factor for sudden cardiac death: the Paris Prospective Study: Circulation, v. 104, no. 7, p. 744-745. Lecerf, J. M., 2009, Fatty acids and cardiovascular disease: Nutr.Rev., v. 67, no. 5, p. 273-283. Leklem, J. E., 1990, Vitamin B-6: a status report: J.Nutr., v. 120 Suppl 11, p. 1503-1507. Leklem, J. E., and C. B. Hollenbeck, 1990, Acute ingestion of glucose decreases plasma pyridoxal 5'-phosphate and total vitamin B-6 concentration: Am.J.Clin.Nutr., v. 51, no. 5, p. 832-836. Lotto, V., S. W. Choi, and S. Friso, 2011, Vitamin B6: a challenging link between nutrition and inflammation in CVD: Br.J.Nutr., v. 106, no. 2, p. 183-195. Lumeng, L., R. E. Brashear, and T. K. Li, 1974, Pyridoxal 5'-phosphate in plasma: source, protein-binding, and cellular transport: J.Lab Clin.Med., v. 84, no. 3, p. 334-343. Lumeng, L., A. Lui, and T. K. Li, 1980, Plasma content of B6 vitamers and its relationship to hepatic vitamin B6 metabolism: J.Clin.Invest, v. 66, no. 4, p. 688-695. Makris, A., and S. N. Gershoff, 1974, Insulin sensitivity in vitamin B 6-deficient rats. Effects of acute and chronic growth hormone treatment: Nutr.Metab, v. 16, no. 6, p. 337-351. Mehansho, H., and L. M. Henderson, 1980, Transport and accumulation of pyridoxine and pyridoxal by erythrocytes: J.Biol.Chem., v. 255, no. 24, p. 11901-11907. Meigs, J. B., D. E. Singer, L. M. Sullivan, K. A. Dukes, R. B. D'Agostino, D. M. Nathan, E. H. Wagner, S. H. Kaplan, and S. Greenfield, 1997, Metabolic control and prevalent cardiovascular disease in non-insulin-dependent diabetes mellitus (NIDDM): The NIDDM Patient Outcome Research Team: Am.J.Med., v. 102, no. 1, p. 38-47. Midttun, O., S. Hustad, J. Schneede, S. E. Vollset, and P. M. Ueland, 2007, Plasma vitamin B-6 forms and their relation to transsulfuration metabolites in a large, population-based study: Am.J.Clin.Nutr., v. 86, no. 1, p. 131-138. Minovic, I. et al., 2017, Vitamin B-6 deficiency is common and associated with poor long-term outcome in renal transplant recipients: Am.J.Clin.Nutr., v. 105, no. 6, p. 1344-1350. Mozaffarian, D., and J. H. Wu, 2011c, Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events: J.Am.Coll.Cardiol., v. 58, no. 20, p. 2047-2067. Mujica-Coopman, M. F., A. B. Franco-Sena, D. R. Farias, J. S. Vaz, A. Brito, G. Kac, and Y. Lamers, 2017, Vitamin B-6 Status in Unsupplemented Pregnant Women Is Associated Positively with Serum Docosahexaenoic Acid and Inversely with the n-6-to-n-3 Fatty Acid Ratio: J.Nutr., v. 147, no. 2, p. 170-178. Musso, G., R. Gambino, and M. Cassader, 2009, Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD): Prog.Lipid Res., v. 48, no. 1, p. 1-26. Nakamura, S., H. Li, A. Adijiang, M. Pischetsrieder, and T. Niwa, 2007, Pyridoxal phosphate prevents progression of diabetic nephropathy: Nephrol.Dial.Transplant., v. 22, no. 8, p. 2165-2174. Nix, W. A., R. Zirwes, V. Bangert, R. P. Kaiser, M. Schilling, U. Hostalek, and R. Obeid, 2015b, Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy: Diabetes Res.Clin.Pract., v. 107, no. 1, p. 157-165. Okada, M., M. Shibuya, E. Yamamoto, and Y. Murakami, 1999c, Effect of diabetes on vitamin B6 requirement in experimental animals: Diabetes Obes.Metab, v. 1, no. 4, p. 221-225. Pawar, A., and D. B. Jump, 2003, Unsaturated fatty acid regulation of peroxisome proliferator-activated receptor alpha activity in rat primary hepatocytes: J.Biol.Chem., v. 278, no. 38, p. 35931-35939. Percudani, R., and A. Peracchi, 2003, A genomic overview of pyridoxal-phosphate-dependent enzymes: EMBO Rep., v. 4, no. 9, p. 850-854. Rimoldi, O. J., G. S. Finarelli, and R. R. Brenner, 2001, Effects of diabetes and insulin on hepatic delta6 desaturase gene expression: Biochem.Biophys.Res.Commun., v. 283, no. 2, p. 323-326. Ringbom, T., U. Huss, A. Stenholm, S. Flock, L. Skattebol, P. Perera, and L. Bohlin, 2001, Cox-2 inhibitory effects of naturally occurring and modified fatty acids: J.Nat.Prod., v. 64, no. 6, p. 745-749. Robinson, K. et al., 1998, Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group: Circulation, v. 97, no. 5, p. 437-443. Rogers, K. S., and C. Mohan, 1994b, Vitamin B6 metabolism and diabetes: Biochem.Med.Metab Biol., v. 52, no. 1, p. 10-17. Roubenoff, R., R. A. Roubenoff, J. Selhub, M. R. Nadeau, J. G. Cannon, L. M. Freeman, C. A. Dinarello, and I. H. Rosenberg, 1995, Abnormal vitamin B6 status in rheumatoid cachexia. Association with spontaneous tumor necrosis factor alpha production and markers of inflammation: Arthritis Rheum., v. 38, no. 1, p. 105-109. Ruidera, E., C. E. Irazu, P. R. Rajagopalan, J. K. Orak, C. T. Fitts, and I. Singh, 1988, Fatty acid metabolism in renal ischemia: Lipids, v. 23, no. 9, p. 882-884. Saibeni, S., M. Cattaneo, M. Vecchi, M. L. Zighetti, A. Lecchi, R. Lombardi, G. Meucci, L. Spina, and F. R. de, 2003, Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants: Am.J.Gastroenterol., v. 98, no. 1, p. 112-117. Sanderson, C. R., and R. E. Davis, 1976, Serum pyridoxal in patients with gastric pathology: Gut, v. 17, no. 5, p. 371-374. Schatteman, G. C., H. D. Hanlon, C. Jiao, S. G. Dodds, and B. A. Christy, 2000b, Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice: J.Clin.Invest, v. 106, no. 4, p. 571-578. Siba, I. P., M. Bortolanza, M. A. B. Frazao Vital, R. Andreatini, J. M. da Cunha, E. A. Del Bel, and J. M. Zanoveli, 2017, Fish oil prevents rodent anxious states comorbid with diabetes: A putative involvement of nitric oxide modulation: Behav.Brain Res., v. 326, p. 173-186. Sinclair, H. M., 1980, Prevention of coronary heart disease: the role of essential fatty acids: Postgrad.Med.J., v. 56, no. 658, p. 579-584. Singer, P., G. Gnauck, G. Honigmann, P. Stolz, V. Schliack, H. Thoelke, L. H. Kettler, and P. Buntrock, 1974, Fatty acid composition of liver triglycerides in various stages of fat deposition in the parenchyma: Acta Diabetol.Lat., v. 11, no. 1, p. 32-42. Solomon, L. R., 1982, Considerations in the use of B6 vitamers in hematologic disorders: I. Red cell transport and metabolism of pyridoxal: Blood, v. 59, no. 3, p. 495-501. Sprecher, H., 1986, The metabolism of (n-3) and (n-6) fatty acids and their oxygenation by platelet cyclooxygenase and lipoxygenase: Prog.Lipid Res., v. 25, no. 1-4, p. 19-28. Talwar, D., T. Quasim, D. C. McMillan, J. Kinsella, C. Williamson, and D. S. O'Reilly, 2003, Optimisation and validation of a sensitive high-performance liquid chromatography assay for routine measurement of pyridoxal 5-phosphate in human plasma and red cells using pre-column semicarbazide derivatisation: J.Chromatogr.B Analyt.Technol.Biomed.Life Sci., v. 792, no. 2, p. 333-343. Tas, S., E. Sarandol, and M. Dirican, 2014a, Vitamin B6 supplementation improves oxidative stress and enhances serum paraoxonase/arylesterase activities in streptozotocin-induced diabetic rats: ScientificWorldJournal., v. 2014, p. 351598. Taugner, R., R. Nobiling, R. Metz, F. Taugner, C. Buhrle, and E. Hackenthal, 1988, Hypothetical interpretation of the calcium paradox in renin secretion: Cell Tissue Res., v. 252, no. 3, p. 687-690. Tiemeier, H., H. R. van Tuijl, A. Hofman, A. J. Kiliaan, and M. M. Breteler, 2003, Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study: Am.J.Clin.Nutr., v. 78, no. 1, p. 40-46. Tong, H., A. G. Rappold, D. Diaz-Sanchez, S. E. Steck, J. Berntsen, W. E. Cascio, R. B. Devlin, and J. M. Samet, 2012, Omega-3 fatty acid supplementation appears to attenuate particulate air pollution-induced cardiac effects and lipid changes in healthy middle-aged adults: Environ.Health Perspect., v. 120, no. 7, p. 952-957. Tsuge, H., N. Hotta, and T. Hayakawa, 2000, Effects of vitamin B-6 on (n-3) polyunsaturated fatty acid metabolism: J.Nutr., v. 130, no. 2S Suppl, p. 333S-334S. Turgeon, J., S. Dussault, F. Maingrette, J. Groleau, P. Haddad, G. Perez, and A. Rivard, 2013a, Fish oil-enriched diet protects against ischemia by improving angiogenesis, endothelial progenitor cell function and postnatal neovascularization: Atherosclerosis, v. 229, no. 2, p. 295-303. Ubbink, J. B., and A. M. Schnell, 1988a, High-performance liquid chromatographic assay of erythrocyte enzyme activity levels involved in vitamin B6 metabolism: J.Chromatogr., v. 431, no. 2, p. 406-412. Valdes-Ramos, R., A. L. Guadarrama-Lopez, B. E. Martinez-Carrillo, and A. D. Benitez-Arciniega, 2015, Vitamins and type 2 diabetes mellitus: Endocr.Metab Immune.Disord.Drug Targets., v. 15, no. 1, p. 54-63. Vanuzzo, D. et al., 2007, Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects: Eur.Heart J., v. 28, no. 4, p. 484-491. Wang, L., A. R. Folsom, Z. J. Zheng, J. S. Pankow, and J. H. Eckfeldt, 2003, Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study: Am.J.Clin.Nutr., v. 78, no. 1, p. 91-98. Wang, X. D., S. Kashii, L. Zhao, A. B. Tonchev, H. Katsuki, A. Akaike, Y. Honda, J. Yamashita, and T. Yamashima, 2002a, Vitamin B6 protects primate retinal neurons from ischemic injury: Brain Res., v. 940, no. 1-2, p. 36-43. Wang, Y. C., W. L. Lin, Y. J. Lin, F. Y. Tang, Y. M. Chen, and E. P. Chiang, 2014, A novel role of the tumor suppressor GNMT in cellular defense against DNA damage: Int.J.Cancer, v. 134, no. 4, p. 799-810. Wei, E. K., E. Giovannucci, J. Selhub, C. S. Fuchs, S. E. Hankinson, and J. Ma, 2005, Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women: J.Natl.Cancer Inst., v. 97, no. 9, p. 684-692. Wei, I. L., 1999, The influence of dietary restriction on vitamin B-6 vitamer distribution and on vitamin B-6 metabolizing enzymes in rats: J.Am.Coll.Nutr., v. 18, no. 2, p. 144-151. Wiktorowska-Owczarek, A., M. Berezinska, and J. Z. Nowak, 2015, PUFAs: Structures, Metabolism and Functions: Adv.Clin.Exp.Med., v. 24, no. 6, p. 931-941. Wilson, R. G., and R. E. Davis, 1977, Serum pyridoxal concentrations in children with diabetes mellitus: Pathology, v. 9, no. 2, p. 95-98. Wolff, S. P., and R. T. Dean, 1987, Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes: Biochem.J., v. 245, no. 1, p. 243-250. Zeghichi-Hamri, S., L. M. de, P. Salen, M. Chibane, L. J. de, F. Boucher, and F. Laporte, 2010, Protective effect of dietary n-3 polyunsaturated fatty acids on myocardial resistance to ischemia-reperfusion injury in rats: Nutr.Res., v. 30, no. 12, p. 849-857. Zhao, M. et al., 2012b, Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women: J.Nutr., v. 142, no. 10, p. 1791-1797. Zhao, M., M. A. Ralat, S. da, V, T. J. Garrett, S. Melnyk, S. J. James, and J. F. Gregory, III, 2013, Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells: Am.J.Physiol Endocrinol.Metab, v. 304, no. 4, p. E342-E351.
摘要: 
維生素B6是水溶性維生素，其活化型磷酸比哆醛 (pyridoxal phosphate, PLP) 在體內參與百種酵素反應包含胺基酸、神經傳遞、核酸、血紅素和脂質等代謝。脂肪酸的組成在生物體細胞膜結構以及能量代謝與儲存中扮演重要角色。異常的脂肪酸分布與許多病理狀態有關，如自體免疫疾病、心血管疾病和糖尿病等。已知較低的血漿活化型磷酸比哆醛濃度是獨立的心血管疾病的危險因子，而提升維生素B6有助於預防心血管疾病，因此維持健康人體內維生素B6濃度有其重要性及生理意義。許多文獻指出攝取富含n-3脂肪酸的魚油有效降低罹患心血管疾病風險，並助於動物後肢缺血模式之恢復後血流，因此無論是調節脂肪酸比例或是增進維生素B6活化型磷酸比哆醛濃度，都對健康人的心血管疾病預防有很大助益。過去雖曾有研究指出維生素B6不足影響體內n-6脂肪酸和n-3脂肪酸的比例，然至今並無任何文獻探究飲食中不同比例脂肪酸如何影響體內維生素B6代謝。本論文是第一個系統性探討飲食配方中不同脂肪酸組成對維生素B6代謝之影響的研究。根據過去本研究室未發表的體外先期研究 (in vitro pilot study) 曾發現特定的脂肪酸會促進維生素B6磷酸化，促進維生素B6活化，也發現特定脂肪酸會抑制維生素B6去磷酸化，進而影響胞內不同形式的維生素B6比例，而特定脂肪酸對重要的維生素B6代謝酵素活性有不同影響。我們因此針對如何有效提升維生素B6活化減少維生素B6降解設計出不同脂肪酸組合之飲食配方，並在小鼠模式中測試不同配方對於體內脂肪酸分佈以及體內維生素B6代謝之影響。實驗結果發現不同油組成的飲食配方對於小鼠維生素B6代謝有不同程度的顯著影響，進一步探討維生素B6與特定其之間的相關性係與可能機制，找出對於維生素B6代謝較為有利的脂肪酸配方組成。本論文是第一個發現特定脂肪酸組成有助於提升維生素B6有研究。

Vitamin B6 is a water-soluble essential nutrient and functions as a coenzyme in 100 enzymatic reactions involved in the metabolism. Vitamin B6 exists as pyridoxal (PL), pyridoxal 5'-phosphate (PLP) as its major bioactive form (Midttun et al., 2007). Low plasma PLP concentrations are independent risk factors for cardiovascular disease, and severe vitamin B-6 deficiency has been associated with altered n-6 and n-3 fatty acid profiles in plasma and tissue lipids (Zhao et al., 2012a). Fatty acids play an important role in the composition of cell membranes and the energy metabolism. Abnormal plasma fatty acid profile is associated with many pathological conditions such as autoimmune disease, cardiovascular disease, and diabetes (Fraser et al., 1999), (Leaf, 2001), (Tiemeier et al., 2003). However, the impact of various dietary fatty acid consumptions on vitamin B6 metabolism has never been investigated before. Our study is the first study reporting that supplementation with new fatty acid formulas on vitamin B6 in vivo. In our pilot in vitro study, and we found that specific fatty acids could alter vitamin B6 metabolism. Therefore, we established different fatty acids formulas to search the most efficient improvement of vitamin B6 in vivo. In our in vitro model, we treated human erythrocytes with different fatty acids and investigated vitamin B6 metabolic enzymes as well as B6 vitamer profile. Three independent in vivo models were used. In the 1st study twelve healthy C57BL/6J mice received either 10% oil rich in omega-3 fatty acid, or 10% soybean oil rich in omega-6 fatty acid for 27 weeks. In the 2nd and 3rd studies, twenty-eight and twenty-nine female C57BL/6J mice were gavaged a PUFA enriched diet containing different omega-3 fatty acids formulas for 21 days. Fatty acid composition was determined by GC-FID. In our study, we found that various dietary fatty acid consumptions had different impacts on vitamin B6 metabolism. We study the relationships among B6 vitamers and fatty acid composition and further explored the potential mechanisms by which specific fatty acid alters vitamin B6 metabolism.
URI: http://hdl.handle.net/11455/96024
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