Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/97317
標題: 計算視網膜下積液體積的演算法
A Computational Algorithm for Subretinal Fluid Volume
作者: 林士桓
Shih-Huan Lin
關鍵字: 視網膜下積液體積;氣球蛇行演算法;模糊函數;組內相關係數;光學相干斷層掃描;subretinal fluid volume;balloon snake algorithm;fuzzy function;intraclass correlation coefficient;optical coherence tomography
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摘要: 
新的眼科儀器檢測技術帶給醫生更方便及準確診治。例如改良式
的檢眼鏡被發明,或是光學相干斷層掃描被引入眼科學,都使眼科醫
生能更準確診斷眼睛的疾病。所以本文希望能建立眼科OCT 影像的
3D 模型,並計算其視網膜下積液的體積,以利於醫生判斷病人恢復
的情況與更準確預估恢復時間。
視網膜下積液的輪廓線為封閉曲線,因此我們建議以氣球蛇行演
算法為主,來近似積液的輪廓線。先採用高斯濾波器與調整亮度的公
式來做前處理,再用三次樣條插值及模糊函數來建立輪廓線的數學模
型,最後建立視網膜下積液的3D 模型,並計算體積。
本論文在經過20 組病例的實測,並與專業人員描繪輪廓線所推估
的體積比較後,其組內相關係數高達0.9934。在計算視網膜下積液的
體積與建立3D 模型上提供了快速、穩定的演算法。

New detection technology of ophthalmic instrument brings more convenience and accuracy on treatment to doctors. For example, the improved ophthalmoscope was invented, and the optical coherence tomography was introduced in ophthalmology. It all helps the ophthalmologists diagnose the eye disease more accurately. As a result, this article aims at establishing a 3D model for eye OCT images and calculating subretinal fluid volume, in that way, we can help doctors to determine the patient''s recovery condition and estimate the recovery time accurately.

Subretinal fluid contour is a closed curve, so we recommend take Balloon Snake as the main algorithm to detect subretinal fluid contour. We first adopt Gaussian filter and brightness adjustment formula to do preprocessing, using cubic spline interpolation and fuzzy function to build the required contours’ mathematical model, finally establish 3D model of subretinal fluid and calculate the volume.

After 20 medical cases, we make the comparison with the calculated volume and the volume estimated by the contour drawn by professional staff, the posterior intraclass correlation coefficient is up to 0.9934. It provides fast and stable algorithms in the calculation of subretinal fluid’s volume and the establishment of the 3D model.
URI: http://hdl.handle.net/11455/97317
Rights: 同意授權瀏覽/列印電子全文服務,2021-02-07起公開。
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