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dc.contributor.authorYu-Fang Linen_US
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dc.description.abstract近年來有許多研究重新利用原有的非抗癌藥物來治療癌症,以節省藥物研發的各項成本,目前已有多項研究指出,部分人們長期使用的非抗癌用藥也具有治療癌症的效果,且售價比癌症用藥來的便宜許多,本實驗從1175個美國FDA核准藥物篩選出88、268、372、426、462、768、840、932、以及1162等9種具有抗癌效果的傳統非抗癌用藥,搜尋現有文獻以確認這些藥物在癌症治療方面的作用機制。結果發現:88可選擇性活化RAR或RXR,誘導癌細胞凋亡,也可作為CDK2抑制劑阻斷癌細胞生長。372與426可作為鈣離子通道阻斷劑,抑制p醣蛋白功能,並可阻斷細胞週期抑制癌細胞生長。462在癌症治療方面的作用機制目前仍不明確,有可能是與其作為多巴胺受體拮抗劑的功能相關。768對於不同癌細胞具有不同的作用途徑,包括:Wnt/β-catenin pathway、mTORC1 pathway、STAT3 pathway、NF-κB pathway以及Notch signal pathway。932會針對DNA修復功能異常的大腸結腸癌及子宮頸癌細胞產生毒性,治療效果主要與抗葉酸功能有關。1162的抗癌機制仍未確定,可能可誘導癌細胞自噬或抑制S100A4功能。268可誘導黑色素體自噬,並增強T細胞清除黑色素瘤功能。840的專利中只提到該藥物具有的抗癌功效,但並未提及作用機制。zh_TW
dc.description.abstractIn recent years, many studies have reused the original non-anticancer drugs to treat cancer, in order to save the cost of drug research and development. Today, many studies have pointed out that some people's long-term use of non-anticancer drugs also have the effect of treating cancer. And the price is much cheaper than that of cancer. This study get 9 drugs repurposing in cancer such as 88, 268, 372, 426, 462, 768, 840, 932, and 1162 from 1175 FDA-approved drugs. We search for existing literature to confirm the mechanism of action of these drugs in cancer treatment. It was found that 88 can selectively activate RAR or RXR to induce apoptosis in cancer cells, and can also act as a CDK2 inhibitor to block the growth of cancer cells. 372 and 426 act as calcium channel blockers, inhibit p-glycoprotein function, and block cell cycle and inhibit cancer cell growth. The mechanism of action of 462 in the treatment of cancer is still unclear and may be related to its function as a dopamine receptor antagonist. 768 has different pathways for different cancer cells, including: Wnt/β-catenin pathway, mTORC1 pathway, STAT3 pathway, NF-κB pathway, and Notch signal pathway. 932 is toxic to colorectal cancer and cervical cancer cells with abnormal DNA repair function, and the therapeutic effect is mainly related to anti-folate function. The anticancer mechanism of 1162 remains undetermined and may induce autophagy in cancer cells or inhibit S100A4 function. 268 induces autophagy of melanosomes and enhances T cell clearance of melanoma. The 840 patent only mentions the anticancer effect of the drug, but does not mention the mechanism of action.en_US
dc.description.tableofcontents一、 緒論 1 (一) 何謂癌症 1 (二) 癌症的治療方式 1 (三) 癌症藥物的高昂費用 1 (四) 研究動機 2 二、 材料與方法 3 (一) 實驗材料(搜尋資料庫) 3 (二) 實驗方法 3 (三) 篩選條件 3 三、 結果 4 (一) 藥物編號:88 4 (二) 藥物編號:426、372 5 (三) 藥物編號:462 6 (四) 藥物編號:768 7 (五) 藥物編號:932 8 (六) 藥物編號:1162 9 (七) 藥物編號:268 10 (八) 藥物編號:840 10 四、 討論 11 五、 參考文獻 13 六、 附錄 16 附錄1:比值清單 16 附錄2:CLINICAL TRIALS搜尋結果 17 附錄3:癌症相關資料搜尋結果 18 附錄4:健保用藥品項網路查詢結果 19 附錄5:426與372對癌細胞的作用機制 20 附錄6:768作用機制 21 附錄7:768作用機制 22 附錄8:932的藥理作用 23 附錄9:造成卵巢癌MMR功能缺陷的異常蛋白 24 附錄10:卵巢癌細胞株的MMR蛋白 25zh_TW
dc.subjectdrug repositionen_US
dc.titleAnalyzing the biochemical mechanisms of anticancer compoundsen_US
dc.typethesis and dissertationen_US
item.openairetypethesis and dissertation-
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