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標題: 柑橘類黃酮柚皮素的止痛與抗發炎作用
Anti-Nociceptive and Anti-Inflammatory Effects of Citrus Flavanone Naringenin
作者: 田易靈
Yi-Ling Tien
關鍵字: 抗發炎作用;止痛;發炎;柚皮素;疼痛;Anti-inflammatory;Anti-nociceptive;Inflammation;Naringenin;Pain
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Shi Y, Dai J, Liu H, Li RR, Sun PL, Du Q, et al. Naringenin inhibits allergen-induced airway inflammation and airway responsiveness and inhibits NF-kappaB activity in a murine model of asthma. Physiol Pharmacol 2009;87:729-3. 17. Moon PD, Choi IH, Kim HM. Naringenin suppresses the production of thymic stromal lymphopoietin through the blockade of RIP2 and caspase-1 signal cascade in mast cells. Eur J Pharmacol 2011;671:128-32. 18. Chao CL, Weng CS, Chang NC, Lin JS, Kao ST, Ho FM. Naringenin more effectively inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in macrophages than in microglia. Nutr Res 2010;30:858-64. 19. Li YR, Chen DY, Chu CL, Li S, Chen YK, Wu CL, et al. Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis. J Nutr Biochem 2015;26:1467-78. 20. Wang HK, Yeh CH, Iwamoto T, Satsu H, Shimizu M, Totsuka M. 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柚皮素(Naringenin),一種被發現在柑橘類水果中的類黃酮,具有顯著多樣的藥理學性質。在本研究中,我們設計有關柚皮素對於止痛與抗發炎作用的相關研究。在大鼠與小鼠身上進行熱板測試、醋酸誘導扭動與甩尾測定來評估柚皮素的抗傷害作用。另外,透過角叉菜誘導的大鼠足腫脹測試來進行柚皮素抗發炎作用。我們發現口服柚皮素(100與200 mg/kg)的老鼠顯著延遲了對於熱板試驗所產生的熱刺激的反應時間,並且甩尾測定與醋酸誘導扭體次數也相對減少。另外,柚皮素在角叉菜誘導爪腫脹的測試中顯著抑制大鼠足腫脹,發揮抗發炎作用。我們的研究結果支持柚皮素具有止痛和抗發炎作用的治療潛力,並且可以進一步用於疼痛與發炎相關疾病的藥物開發。

Naringenin, a flavonoid found in citrus fruits, has notably diverse pharmacological properties. In the present study, we designed to investigate the anti-nociceptive and anti-inflammatory effects of the naringenin.
The anti-nociceptive effect was evaluated using hot-plate, acetic acid-induced writhing, and tail-flick assays in mice and rats. In addition, the anti-inflammatory effect was examined by carrageenan induced paw edema test in rats.
Naringenin (100, 200 mg/kg, oral administration) significantly delayed the reaction time of mice to the thermal stimulation generated with the hot-plate, and tail-flick unit and reduced acetic acid-induced writhing response in mice. In addition, naringenin significantly repressed the paw edema induced by carrageenan in rats, exerting its anti-inflammatory effect.
Our results support that the naringenin has therapeutic potential with anti-nociceptive and anti-inflammatory properties and can be further exploitable for drug development of pain and inflammatory related diseases.
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