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Foreign Proteostasis Hub Hsp90 Promotes Network Evolution in Saccharomyces cerevisiae
Tracy Chih-Ting Koubkova Yu
|關鍵字:||熱休克蛋白;基因網絡;網絡中心;網絡演化;實驗演化;表現新多樣化;基因多效性;演化多樣化;Hsp90;network hub;network evolution;experimental evolution;phenotypic innovation;pleiotropy;phenotypic diversity;evolutionary diversification||引用:||Reference 1. Hartwell, L.H., et al., From molecular to modular cell biology. Nature, 1999. 402(6761 Suppl): p. C47-52. 2. Barabasi, A.L. and Z.N. Oltvai, Network biology: understanding the cell's functional organization. Nat Rev Genet, 2004. 5(2): p. 101-13. 3. Eisenberg, D., et al., Protein function in the post-genomic era. Nature, 2000. 405(6788): p. 823-6. 4. Proulx, S.R., D.E. Promislow, and P.C. Phillips, Network thinking in ecology and evolution. Trends Ecol Evol, 2005. 20(6): p. 345-53. 5. Jeong, H., et al., Lethality and centrality in protein networks. Nature, 2001. 411(6833): p. 41-2. 6. Batada, N.N., L.D. Hurst, and M. Tyers, Evolutionary and physiological importance of hub proteins. PLoS Comput Biol, 2006. 2(7): p. e88. 7. Levy, S.F. and M.L. 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Biological processes in living cells are often carried out by gene networks in which signals and reactions are integrated at network hubs, which play fundamental roles for maintaining the cell physiology through interacting highly with other genes. Network hubs are responsivle for collecting signals from the upstream genes and then tune the cellular outputs in correspondent to the environmental cues. Hub genes are known to be evolutionary conserved and even slight perturbations of the sequences can lead to deleterious cell growth. Despite of the functional constraint, the sequences of the hub genes still change along the time. It is unclear to what extent the natural sequence variation actually contributes to functional divergence and to what extent network hubs are evolvable. Furthermore, to our knowledge no study has ever addressed how these alterations impact long-term evolution. We investigated these questions using a protein homeostasis central hub, heat shock protein (Hsp90) wich is essential under the normal condition for maintaining the normal cell growth. When native Hsp90 in Saccharomyces cerevisiae cells was replaced by the ortholog from hypersaline-tolerant Yarrowia lipolytica that diverged from S. cerevisiae about 270 million years ago, the cells exhibited improved growth in hypersaline environments but compromised growth in others, indicating functional divergence in Hsp90 between the two yeasts. Laboratory evolution shows that evolved Y. lipolytica-HSP90-carrying S. cerevisiae cells exhibit a wider range of phenotypic variation than cells carrying native HSC82. Identified beneficial mutations are involved in multiple pathways and are often pleiotropic. Our results show that cells adapt to a heterologous Hsp90 by modifying different sub-networks, facilitating the evolution of phenotypic diversity inaccessible to wild-type cells.
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