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The development of the aqueous-organic liquid-liquid micro-extraction technology with continuous coaxial flow
|關鍵字:||液-液萃取;針扎效應;連續同軸流;liquid-liquid extraction;pinning effect;continuous coaxial flow||引用:|| K. V. Gernaey, A. E. Cervera-Padrell, and J. M. Woodley, 'Development of continuous pharmaceutical production processes supported by process systems engineering methods and tools,' Future Medicinal Chemistry, vol. 4, no. 11, pp. 1371-1374, 2012/07/01 2012.  陳洪章, '生物程序工程與設備 Bioprocess Engineering And Equipment.' NEW WCDP, p.^pp. Pages.  J. P. Brody and P. Yager, 'Diffusion-based extraction in a microfabricated device,' Sensors and Actuators A: Physical, vol. 58, no. 1, pp. 13-18, 1997/01/01/ 1997.  M. Lubej, U. Novak, M. Liu, M. Martelanc, M. Franko, and I. Plazl, Microfluidic Droplet-Based Liquid–Liquid Extraction: Online Model Validation. 2015.  P. Mary, V. Studer, and P. Tabeling, 'Microfluidic Droplet-Based Liquid−Liquid Extraction,' Analytical Chemistry, vol. 80, no. 8, pp. 2680-2687, 2008/04/15 2008.  I. 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研究中水溶液相包含50 mM的-甲基芐胺(-methylbenzylamine, -MBA)以及苯乙酮(acetophenone, APH)，有機溶劑相為正庚烷(n-heptane)，以此來模擬苯乙酮生產流程中的純化作業。實驗中測試了在線圈間距從0.156到0.335 mm下適用的操作範圍，從實驗結果得知操作範圍涵蓋從0.5至7300 l/min，另外一相液體中也無液珠生成；在得知裝置的流率適用範圍後，也驗證了在不同設置下的裝置中之萃取效率。
In recent years, bioengineering technology has flourished and is widely used in the pharmaceutical industry. From raw materials to processed drugs, it can be roughly divided into upstream pretreatment, midstream reaction and downstream purification. Each stage contains various bioprocessing technology. As long as you change one parameter of the steps, it will affect the yield. It also makes the drug development in the process takes a lot of money and time. In order to reduce the production cost, the
techniques for miniaturizing devices in bioengineering have also emerged.
The final output and quality of the product are mainly affected by downstream processing. The downstream processing utilizes the different physical properties and chemical properties of the reactants in process to separate and purify the product. In this study, the miniaturization system for liquid-liquid extraction was discussed. Among the existing miniaturized liquid-liquid extraction systems, there are three of the most common techniques: droplet based liquid-liquid extraction, membrane based liquid-liquid and co-flow liquid-liquid extraction systems. The development of these three technologies is limited in their use. But these three technologies are limited in their use.
In order to overcome the limitations of the above three technologies, the purpose of this study was to develop a system that can be continuously flowed, has a wide operating range, has a stable aqueous-organic phase contact area, and does not require an additional liquid separation device. To achieve the purpose, a helix wire is added into the device to make the aqueous solution flow only in the helix wire and form a stable contact surface with the organic solvent due to the Laplace pressure. The extraction is carried out by continuous coaxial flow; The pitches of the helix wire are adjustable by stretching or compressing the helix wire. To allow the device to have a stable liquid contact area at different flow rates to complete the extraction. The system also optimizes bioprocessing efficiency by changing contact time, pH, and changing extractant.
In the study, the aqueous phase contained 50 mM of -methylbenzylamine (-MBA) and acetophenone (APH), and the organic solvent phase was n-heptane, which was used to simulate the purification operations in the acetophenone production process. In the experiment, the applicable operating range of helix wire pitches are from 0.156 to 0.335 mm was tested. From the experimental results, the operating range was from 0.5 to 7300 l/min, and no droplet was formed in the other phase liquid. After the flow rate is applied, the extraction efficiency in the device at different settings is also verified.
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