Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/98499
標題: 運用雌激素醌類代謝物蛋白質胼合物作為子宮內膜癌預防醫學之生物指標
Application of estrogen quinone-derived protein adducts as biomarkers of Endometrial cancer in preventive medicine.
作者: 林昱廷
Yu-Ting Lin
關鍵字: 子宮內膜癌;子宮肌瘤;雌激素;Endometrial cancer;Leiomyoma;estrogen
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摘要: 
17β-雌二醇-2,3-醌 (E2-2,3-Q) 和17β-雌二醇-3,4-醌 (E2-3,4-Q) 為雌性激素活性代謝物,被認為是誘發基因毒性之主因。本研究的目的是分析正常人 (n = 20),子宮肌瘤病人 (n = 20) 以及子宮內膜癌病人 (n = 20) 之雌性激素醌類代謝物血清白蛋白胼合物,並利用雌性激素醌類代謝物血清白蛋白胼合物之背景值建立台灣女性子宮內膜癌預測模式之研究。其中生物指標包含E2-3,4-Q-2-S-Alb,E2-2,3-Q-4-S-Alb 以及E2-3,4-Q-2-S-Alb和E2-2,3-Q-4-S-Alb這三個指標,以通過混合模式篩選罹患子宮內膜癌之高風險族群。
混合模型利用統合正常人,子宮肌瘤病人以及子宮內膜癌病人之雌性激素醌類代謝物血清白蛋白胼合物背景值。計算雌性激素醌類代謝物血清白蛋白胼合物之平均值,並作為子宮內膜癌風險 (高風險和低風險之指標)。比較每個族群個體間年齡以及BMI之特徵。並且,估計篩選模式之預測值,偽陽性 (False positive)以及偽陰性 (False negative) 之比率。
結果顯示,正常人、子宮肌瘤病人以及子宮內膜癌病人之雌性激素醌類代謝物蛋白質胼合物E2-3,4-Q-2-S-Alb以及E2-2,3-Q-4-S-Alb之背景值。其中E2-3,4-Q-2-S-Alb與E2-2,3-Q-4-S-Alb (n = 60) 具有顯著相關性 (r = 0.915,p <0.001)。 總體而言,此一研究結果顯示,雌性激素醌類代謝物血清白蛋白胼合物之背景值與子宮內膜癌之風險無關。未來有必要再進一步調查以驗證這些初步結果。

Both 17β-estradiol-2,3-quinone (E2-2,3-Q) and 17β-estradiol-3,4-quinone (E2-3,4-Q) are reactive metabolites of estrogen that are thought to be responsible for the estrogen-induced genotoxicity. The aim of this study was to analyze estrogen quinone-derived adducts in albumin (Alb) derived from, healthy controls (n=20), leiomyoma patients (n=20), and endometrial cancer patients (n=20) and to establish a prediction model of endometrial cancer by using the background values of estrogen quinone-derived Alb adducts in Taiwanese women. The biomarkers included 3 indicators, i.e., E2-3,4-Q-2-S-Alb, E2-2,3-Q-4-S-Alb, and summation of E2-3,4-Q-2-S-Alb and E2-2,3-Q-4-S-Alb, to screen for high risk individuals of developing endometrial cancer by the mixed model.
Mixed model utilizes the background levels of protein adducts derived from the combined pool of healthy controls, leiomyoma patients, and endometrial cancer patients. The mean values of estrogen quinone-derived Alb adducts were calculated and served as indicators of endometrial cancer risk (high and low risk). Subjects' characteristics for each group of individuals in terms of age and BMI were compared. Additionally, the predictive values, false positive rates, and false negative rates of the screening model were estimated..
Results confirmed that levels of estrogen quinone-derived adducts, including E2-3,4-Q-2-S-Alb and E2-2,3-Q-4-S-Alb, were detected in all three groups of subjects. Levels of E2-3,4-Q-2-S-Alb correlated significantly with those of E2-2,3-Q-4-S-Alb (n=60) (correlation coefficient r= 0.915, p<0.001). Overall, this evidence suggests that the levels of these adducts in human Alb did not associate with risk of developing endometrial cancer. Further investigation is warranted to verify these preliminary findings.
URI: http://hdl.handle.net/11455/98499
Rights: 同意授權瀏覽/列印電子全文服務,2018-08-13起公開。
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