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標題: Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication
作者: Jhang, Jhih-Jia
Lin, Jia-Hong
Yen, Gow-Chin
關鍵字: IL-1β;NLRP3;gout;monosodium urate;phytochemicals;Animals;Antioxidants;Crystallization;Diet;Flavonoids;Gout;Humans;Inflammasomes;Interleukin-1beta;NLR Family, Pyrin Domain-Containing 3 Protein;Phytochemicals;Phytotherapy;Resveratrol;Stilbenes;Uric Acid
Project: Journal of agricultural and food chemistry, Volume 66, Issue 4, Page(s) 765-772.
Gouty arthritis is characterized by the precipitation of monosodium urate (MSU) crystals in the joint. Pro-inflammatory cytokine IL-1β is a critical manifestation in response to MSU crystals attack. IL-1β secretion is dependent on the nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome. Abnormal activation of the NLRP inflammasome is related to cellular oxidative stress. However, recent studies have illustrated that phytochemicals with potent antioxidant activity exert inhibitory effects on NLRP3 inflammasome-mediated diseases. This review focuses on the current findings of studies on the NLRP3 inflammasome and the proposed mechanisms that MSU crystals trigger inflammation via activation of the NLRP3 inflammasome. We also summarized the potential use of phytochemicals on NLRP3 inflammasome-mediated diseases, suggesting that phytochemicals can further prevent acute gout attack.
DOI: 10.1021/acs.jafc.7b05113
Appears in Collections:食品暨應用生物科技學系

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