Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/99080
標題: Effect of Phyllanthus emblica L. fruit on methionine and choline-deficiency diet-induced nonalcoholic steatohepatitis
作者: Tung, Yu-Tang
Huang, Cheng-Ze
Lin, Jia-Hong
Yen, Gow-Chin
顏國欽
關鍵字: Lipid peroxidation;Methionine and choline-deficiency diet;Nonalcoholic steatohepatitis;Oxidative stress;Phyllanthus emblica;Animals;Choline;Diet;Fruit;Humans;Interleukin-1beta;Lipid Peroxidation;Liver;Male;Methionine;Mice;Mice, Inbred C57BL;Non-alcoholic Fatty Liver Disease;Phyllanthus emblica;Plant Extracts;Tumor Necrosis Factor-alpha
Project: Journal of food and drug analysis, Volume 26, Issue 4, Page(s) 1245-1252.
摘要: 
Phyllanthus emblica L. fruit contains abundant bioactive components and exhibits a variety of biological activities. In this study, the hepatoprotective effect of water extract of P. emblica (WEPE) on nonalcoholic steatohepatitis (NASH) was evaluated. C57BL/6 mice were fed methionine and choline-deficiency diet (MCD diet) for 4 or 8 weeks to induce NASH. Results showed that administration of WEPE could significantly reduce serum AST and ALT as compared to MCD diet-alone group. Administration of WEPE could significantly decrease lipid peroxidation and CYP2E1 mRNA expression, and elevate the antioxidant activities in mice livers. In addition, administration of WEPE after 8 weeks could significantly decrease the mRNA expressions of TNF-α and IL-1β in mice livers, but have less improving effect of hepatic steatosis and mononuclear cell infiltration. Taken together, MCD diet might cause serious hepatic steatosis and mild inflammation in mice livers, but administration of WEPE could ameliorate the rapid progression of NASH.
URI: http://hdl.handle.net/11455/99080
ISSN: 1021-9498
DOI: 10.1016/j.jfda.2017.12.005
Appears in Collections:食品暨應用生物科技學系

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