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標題: Synthesis and Bioassay of Neurogenically Potent Gangliosides DSG-A, Hp-s1 and Their Analogues
作者: Shelke, Ganesh B
Lih, Yu-Hsuan
Liao, Ying-Ju
Liang, Chih-Wu
Kuo, Tzer-Min
Ko, Ying-Chin
Luo, Shun-Yuan
關鍵字: Ganglioside Hp-s1;IL-17A;SH-SY5Y cells;analogues;hydrophobicity;neurogenic activity;Cell Line;G(M1) Ganglioside;Gangliosides;Humans;Neurites;Neuroblastoma;Neurogenesis;Tumor Cells, Cultured;Biological Assay
Project: ACS chemical neuroscience, Volume 9, Issue 6, Page(s) 1264-1268.
In the search of a potent candidate for neurotherapy, we designed and synthesized various analogues of ganglioside Hp-s1. The modification includes the change in hydrophobicity by varying the carbon chain length, altering the number of hydrogen bonds, and replacing the anomeric atom. The chemical synthesis was carried out by using various methods and discussed in details. The neuritogenic activities of these analogues are confirmed in a human neuroblastoma cell line SH-SY5Y. A higher activity of ganglioside Hp-s1 analogue on IL-17A transcript upregulation than ganglioside Hp-s1 was found.
DOI: 10.1021/acschemneuro.8b00055
Appears in Collections:化學系所

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