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標題: Palladium-Catalyzed Synthesis of 2,3-Diaryl- N-methylindoles from ortho-Alkynylanilines and Aryl Pinacol Boronic Esters
作者: Luo, Yue-Gui
Basha, R Sidick
Reddy, Daggula Mallikarjuna
Xue, Yong-Jing
Chen, Te-Hsuan
Lee, Chin-Fa
Project: Organic letters, Volume 20, Issue 21, Page(s) 6872-6876.
A palladium-catalyzed synthesis of 2,3-diaryl- N-methylindoles from o-alkynylanilines and aryl pinacol boronic esters was developed. The system possesses high functional group tolerance and a broad substrate scope with a variety of aryl pinacol boronic esters to provide valuable 2,3-diaryl- N-methylindoles in moderate to good yields. Remarkably, the sequential reaction controlled by iridium-catalyzed C-H borylation or palladium-catalyzed alkynylation followed by the present palladium-catalyzed C3 arylation reaction provided functionalized 2,3-diaryl- N-methylindoles in good yields.
DOI: 10.1021/acs.orglett.8b02835
Appears in Collections:化學系所

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