Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/99274
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dc.contributor.authorLin, Li-Chingzh_TW
dc.contributor.authorChen, Chung-Yizh_TW
dc.contributor.authorKuo, Chia-Hungzh_TW
dc.contributor.authorLin, Yun-Shengzh_TW
dc.contributor.authorHwang, Byeong Heezh_TW
dc.contributor.authorWang, Tina Kaitingzh_TW
dc.contributor.authorKuo, Yueh-Hsiungzh_TW
dc.contributor.authorWang, Hui-Min Davidzh_TW
dc.contributor.author王惠民zh_TW
dc.date2018-
dc.date.accessioned2019-12-04T01:31:05Z-
dc.date.available2019-12-04T01:31:05Z-
dc.identifier.urihttp://hdl.handle.net/11455/99274-
dc.description.abstractN-Hydroxycinnamoylphenalkylamides (36H) exhibited both antioxidation and antityrosinase abilities. The compound was studied for its antioxidative properties, using a 1,1-diphenyl-2-picrylhydrazul- (DPPH-) scavenging test, a ferric ion-reducing antioxidant power assay (FRAP) assessment, and a metal-chelating power assay. The results showed that 36H had antioxidative capabilities in the DPPH-scavenging and ferric-reducing power examinations but the chelating power assay did not demonstrate antioxidative capability. 36H was also measured for tyrosinase inhibitory activity applying various species platforms, including in vitro mushroom, B16F10 mouse melanoma, and human melanocyte cells. In terms of in vitro mushroom tyrosinase suppression, 36H restrained the melanogenesis processes. It is assumed that 36H blocked the tyrosinase active site as a competitive inhibitor for mushroom tyrosinase, hence not decreasing the human normal melanocyte cellular viability. A quantitative real-time polymerase chain reaction (qRT-PCR) and western blot discovered that 36H downregulated melanogenesis-related RNA and proteins, including pigment production (MITF, tyrosinase, TRP-1, and TRP-2), melanosome maturation (Rab27a), and melanosome transportation (Myo5a, MLPH and Mreg). Overall, 36H displayed the biofunctions of antioxidation and melanin suppression, so there was a possibility for its application as a food additive or a skin-whitening agent.zh_TW
dc.language.isoenzh_TW
dc.relationOxidative medicine and cellular longevity, Volume 2018, Page(s) 6354972.zh_TW
dc.subjectAnimalszh_TW
dc.subjectAntioxidantszh_TW
dc.subjectCinnamateszh_TW
dc.subjectEnzyme Inhibitorszh_TW
dc.subjectHumanszh_TW
dc.subjectMelaninszh_TW
dc.subjectMelanocyteszh_TW
dc.subjectMicezh_TW
dc.subjectMonophenol Monooxygenasezh_TW
dc.subjectSkin Lightening Preparationszh_TW
dc.title36H: A Novel Potent Inhibitor for Antimelanogenesiszh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1155/2018/6354972zh_TW
dc.awards2018zh_TW
item.grantfulltextrestricted-
item.fulltextwith fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
Appears in Collections:生醫工程研究所
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