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標題: Marine-derived protein kinase inhibitors for neuroinflammatory diseases
作者: Ning, Chong
Wang, Hui-Min David
Marine-derived protein kinase inhibitors for neuroinflammatory diseases
Gao, Rong
Chang, Yu-Chia
Hu, Fengqing
Meng, Xianjun
Huang, Shi-Ying
關鍵字: Glia;Immune cells;In vivo;Marine;Neuroinflammation;Protein kinase inhibitors;Animals;Aquatic Organisms;Humans;Inflammation;Nervous System Diseases;Protein Kinase Inhibitors
Project: Biomedical engineering online, Volume 17, Issue 1, Page(s) 46.
Neuroinflammation is primarily characterized by overexpression of proinflammatory mediators produced by glial activation or immune cell infiltration. Several kinases have been shown to be critical mediators in neuroinflammation. One of the largest groups of kinases is protein kinases, which have been the second most studied group of drug targets after G-protein-coupled receptors. Thus far, most of the approved kinase inhibitor drugs are adenosine triphosphate-competitive inhibitors with various off-target liabilities because of cross-reactivities; however, marine-derived compounds provide opportunities for discovering allosteric kinase inhibitors. This review summarizes the potential of marine-derived protein kinase inhibitors in the field of neuroinflammatory diseases, such as Parkinson disease, Alzheimer disease, multiple sclerosis, and pain. The previous studies from 1990 to 2017 in this review have shown that marine-derived protein kinase inhibitors have great potential to elicit anti-neuroinflammatory or neuroprotective responses in in vitro and in vivo models of neuroinflammatory diseases. This suggests that further exploration and investigation of these marine-derived protein kinase inhibitors on neuroinflammatory diseases are warranted. Therefore, this review may inspire further discovery of new protein kinase inhibitors from a marine origin and additional neuroscience studies focusing on these valuable marine-derived protein kinase inhibitors.
DOI: 10.1186/s12938-018-0477-5
Appears in Collections:生醫工程研究所

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