Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/99322
標題: YY1 and HDAC9c transcriptionally regulate p38-mediated mesenchymal stem cell differentiation into osteoblasts
作者: Chen, Ya-Huey
Chung, Chiao-Chen
Liu, Yu-Chia
Lai, Wei-Chen
Lin, Zong-Shin
Chen, Tsung-Ming
Li, Long-Yuan
李龍緣
Hung, Mien-Chie
關鍵字: HDAC9c;Osteogenesis;YY1;mesenchymal stem cells;p38
Project: American journal of cancer research, Volume 8, Issue 3, Page(s) 514-525.
摘要: 
Mesenchymal stem cells (MSCs) have a high self-renewal potential and can differentiate into various types of cells, including adipocytes, osteoblasts, and chondrocytes. Previously, we reported that the enhancer of zeste homolog 2 (EZH2), the catalytic component of the Polycomb-repressive complex 2, and HDAC9c mediate the osteogenesis and adipogenesis of MSCs. In the current study, we identify the role of p38 in osteogenic differentiation from a MAPK antibody array screen and investigate the mechanisms underlying its transcriptional regulation. Our data show that YY1, a ubiquitously expressed transcription factor, and HDAC9c coordinate p38 transcriptional activity to promote its expression to facilitate the osteogenic potential of MSCs. Our results show that p38 mediates osteogenic differentiation, and this has significant implications in bone-related diseases, bone tissue engineering, and regenerative medicine.
URI: http://hdl.handle.net/11455/99322
ISSN: 2156-6976
Appears in Collections:生命科學系所

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