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|標題:||Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells||作者:||Chen, Huei-Yu
Chueh, Pin Ju
|關鍵字:||Apoptosis;Oxaliplatin;ROS;Sirtuin 1 (SIRT1);Tumor-associated NADH oxidase (tNOX or ENOX2);p53;Cell Line, Tumor;Colonic Neoplasms;Humans;NADH, NADPH Oxidoreductases;Oxaliplatin;Reactive Oxygen Species;Transfection;Tumor Suppressor Protein p53||Project:||Journal of experimental & clinical cancer research : CR, Volume 37, Issue 1, Page(s) 161.||摘要:||
Oxaliplatin belongs to the platinum-based drug family and has shown promise in treating cancer by binding to DNA to induce cytotoxicity. However, individual patients show diverse therapeutic responses toward oxaliplatin due to yet-unknown underlying mechanisms. We recently established that oxaliplatin also exert its anti-cancer activity in gastric cancer cell lines by targeting tumor-associated NADH oxidase (tNOX), attenuate NAD+ generation and reduce NAD+-dependent sirtuin 1 (SIRT1) deacetylase activity, which in turn enhances p53 acetylation and apoptosis.
|Appears in Collections:||生醫工程研究所|
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