Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/99340
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dc.contributor.authorYang, Guliangzh_TW
dc.contributor.authorLi, Shimingzh_TW
dc.contributor.authorYang, Yiwenzh_TW
dc.contributor.authorYuan, Lizh_TW
dc.contributor.authorWang, Peileizh_TW
dc.contributor.authorZhao, Huizh_TW
dc.contributor.authorHo, Chi-Tangzh_TW
dc.contributor.authorLin, Chi-Chenzh_TW
dc.contributor.author林季千zh_TW
dc.date2018-08-08-
dc.date.accessioned2020-01-21T01:54:53Z-
dc.date.available2020-01-21T01:54:53Z-
dc.identifier.urihttp://hdl.handle.net/11455/99340-
dc.description.abstractPsoriasis is a chronic and benign proliferative skin disease. Flavonoids in chenpi (aged tangerine peel) from tangerine ( Citrus reticulate Blanco), such as nobiletin (Nob), tangeretin, and 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone (5-HPMF), possess anti-inflammation and regulation of immune activity among others. In this study, psoriasis-like skin lesions were induced by 12- O-tetradecanoylphorbol-13-acetate (TPA), and the preventive effect of Nob and 5-HPMF on psoriasis-like skin lesions was evaluated. Results showed that skin lesions were dramatically reduced by Nob and 5-HPMF. Levels of cytokines, including interleukin (IL)-1β, IL-17, IL-4, IL-6, tumor necrosis factor-α, and interferon-γ, were also reduced after Nob and 5-HPMF treatment. The expression levels of p-ERK1/2 and p-p38 mitogen-activated protein kinase (MAPK) in the TPA group were 5.3, 4.8, and 5.7 but downregulated to 2.7, 2.9, and 2.3 in the Nob group and 2.4, 2.7, and 1.2 in the 5-HPMF group, respectively ( p ≤ 0.05). The expression of transcription factors Ki-67 and proliferating cell nuclear antigen (PCNA) and the differentiation of CD4+ T cells were reduced by downregulating the expression of the MAPK signaling pathways. The expression levels in TPA, Nob, and 5-HPMF groups were 0.649 ± 0.094, 0.218 ± 0.034, and 0.193 ± 0.042 for Ki-67 and 0.753 ± 0.114, 0.315 ± 0.094, and 0.294 ± 0.035 for PCNA, respectively. Moreover, 5-HPMF showed stronger reduction activity in the prevention of psoriasis than Nob, indicating that the 5-hydroxyl group facilitated the suppression of psoriasis.zh_TW
dc.language.isoenzh_TW
dc.relationJournal of agricultural and food chemistry, Volume 66, Issue 31, Page(s) 8299-8306.zh_TW
dc.subjectCD4+ T cellszh_TW
dc.subjectMAPKzh_TW
dc.subjectnobiletinzh_TW
dc.subjectpsoriasiszh_TW
dc.subjecttranscription factorszh_TW
dc.subjectAnimalszh_TW
dc.subjectCD4-Positive T-Lymphocyteszh_TW
dc.subjectCitruszh_TW
dc.subjectFemalezh_TW
dc.subjectFlavoneszh_TW
dc.subjectFruitzh_TW
dc.subjectGene Expressionzh_TW
dc.subjectKi-67 Antigenzh_TW
dc.subjectMAP Kinase Signaling Systemzh_TW
dc.subjectMicezh_TW
dc.subjectMice, Inbred BALB Czh_TW
dc.subjectProliferating Cell Nuclear Antigenzh_TW
dc.subjectPsoriasiszh_TW
dc.subjectSignal Transductionzh_TW
dc.subjectTetradecanoylphorbol Acetatezh_TW
dc.titleNobiletin and 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone Ameliorate 12- O-Tetradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by Regulating the Expression of Ki-67 and Proliferating Cell Nuclear Antigen and the Differentiation of CD4+ T Cells through Mitogen-Activated Protein Kinase Signaling Pathwayszh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1021/acs.jafc.8b02524zh_TW
dc.awards2018zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextwith fulltext-
item.languageiso639-1en-
item.grantfulltextrestricted-
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