Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/99348
DC FieldValueLanguage
dc.contributor.authorSatange, Roshanzh_TW
dc.contributor.authorChang, Chung-Kezh_TW
dc.contributor.author侯明宏zh_TW
dc.contributor.authorHou, Ming-Honzh_TW
dc.date2018-
dc.date.accessioned2020-02-04T02:25:47Z-
dc.date.available2020-02-04T02:25:47Z-
dc.identifier.urihttp://hdl.handle.net/11455/99348-
dc.description.abstractThe structure of the DNA duplex is arguably one of the most important biological structures elucidated in modern history. DNA duplex structure is closely associated with essential biological functions such as DNA replication and RNA transcription. In addition to the classical A-, B- and Z-DNA conformations, DNA duplexes are capable of assuming a variety of alternative conformations depending on the sequence and environmental context. A considerable number of these unusual DNA duplex structures have been identified in the past decade, and some of them have been found to be closely associated with different biological functions and pathological conditions. In this manuscript, we review a selection of unusual DNA duplex structures, particularly those originating from base pair mismatch, repetitive sequence motifs and ligand-induced structures. Although the biological significance of these novel structures has not yet been established in most cases, the illustrated conformational versatility of DNA could have relevance for pharmaceutical or nanotechnology development. A perspective on the future directions of this field is also presented.zh_TW
dc.language.isoenzh_TW
dc.relationNucleic acids research, Volume 46, Issue 13, Page(s) 6416-6434.zh_TW
dc.subjectDNAzh_TW
dc.subjectImidazoleszh_TW
dc.subjectLigandszh_TW
dc.subjectMetals, Heavyzh_TW
dc.subjectNucleic Acid Conformationzh_TW
dc.subjectNucleotideszh_TW
dc.subjectNylonszh_TW
dc.subjectPyrroleszh_TW
dc.subjectTandem Repeat Sequenceszh_TW
dc.subjectBase Pair Mismatchzh_TW
dc.titleA survey of recent unusual high-resolution DNA structures provoked by mismatches, repeats and ligand bindingzh_TW
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1093/nar/gky561zh_TW
dc.awards2018zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextwith fulltext-
item.languageiso639-1en-
item.grantfulltextrestricted-
Appears in Collections:基因體暨生物資訊學研究所
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