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標題: Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection
作者: Richart, Sarah M
Li, Yi-Lin
Mizushina, Yoshiyuki
Chang, Yuan-Yen
Chung, Tse-Yu
Chen, Guan-Heng
Tzen, Jason Tze-Cheng
Shia, Kak-Shan
Hsu, Wei-Li
關鍵字: Antiviral;Curcumin;Haemagglutinin;Influenza virus;Synergic;Animals;Antiviral Agents;Curcumin;Dogs;Drug Synergism;Humans;Influenza A virus;Influenza, Human;Madin Darby Canine Kidney Cells;Phosphorylation;Proto-Oncogene Proteins c-akt;Virus Replication
Project: Journal of food and drug analysis, Volume 26, Issue 3, Page(s) 1015-1023.
Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a structural analogue of Cur, differs from Cur by acetyl modification, but retains enone groups. Comparative analysis revealed MAC effectively inhibited influenza virus infection (IAV) to a similar extent as, if not superior to, curcumin. Both compounds mildly reduced viral NA activity. Surprisingly, unlike Cur, the MAC inhibition of IAV did not occur through the blocking of HA activity. However, MAC strongly dampened Akt phosphorylation, the prerequisite signalling for efficient IAV propagation. A much stronger inhibition effect on IAV infection was observed when MAC treatment was in combination with Cur. Collectively, MAC demonstrated clear antiviral activity, and likely inhibited IAV via multiple mechanisms that were not identical to Cur. Importantly, Cur and MAC in combination synergistically inhibited IAV infection.
ISSN: 1021-9498
DOI: 10.1016/j.jfda.2017.12.006
Appears in Collections:微生物暨公共衛生學研究所

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