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標題: The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells
作者: Joseph, Nithila A
Chiou, Shiow-Her
Lung, Zoe
Yang, Cheng-Lin
Lin, Tze-Yi
Chang, Hui-Wen
Sun, H Sunny
Gupta, Sachin Kumar
Yen, Laising
Wang, Shulhn-Der
Chow, Kuan-Chih
關鍵字: CCDC66;EGFR;EMT;HGF;SAE2;SUMOylation;c-MET;cirRNA;Adenocarcinoma;Cell Line;Cell-Free Nucleic Acids;Drug Resistance;Epithelial-Mesenchymal Transition;ErbB Receptors;Eye Proteins;Gene Expression;Hepatocyte Growth Factor;Humans;Lung Neoplasms;Metabolic Networks and Pathways;Proto-Oncogene Proteins c-met;Ubiquitin-Activating Enzymes
Project: Journal of hematology & oncology, Volume 11, Issue 1, Page(s) 74.
Epithelial-to-mesenchymal transition (EMT) has, in recent years, emerged as an important tumor cell behavior associated with high metastatic potential and drug resistance. Interestingly, protein SUMOylation and hepatocyte growth factor could respectively reduce the effect of small molecule inhibitors on tyrosine kinase activity of mutated epidermal growth factor receptor of lung adenocarcinomas (LADC). The actual mechanism is yet to be resolved.
DOI: 10.1186/s13045-018-0557-9
Appears in Collections:微生物暨公共衛生學研究所

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